Literature DB >> 18350640

Paraneoplastic hyperinsulinism and secondary hypoglycaemia in a patient with advanced colon cancer: a rare association.

Roberto Díaz1, Jorge Aparicio, Andrea Mendizábal, Marisa Faus, Tania Fleitas, Francisco Aparisi, Maria Martín.   

Abstract

We review the case of a 74-year-old patient with advanced colon cancer who suffered recurrent bouts of hypoglycemia. A state of inappropriate, non-suppressed hyperinsulinism in the presence of severe hypoglycemia was diagnosed. We finally discuss the known mechanisms behind fasting hypoglycemia in patients with advanced cancer, the diagnosis, and possible treatments of this rare paraneoplastic endocrine complication.

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Year:  2008        PMID： 18350640      PMCID： PMC2700411          DOI： 10.3748/wjg.14.1952

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  11 in total

1.  Tumor-induced hypoglycemia.

Authors:  D Le Roith
Journal:  N Engl J Med       Date:  1999-09-02       Impact factor: 91.245

Review 2.  Classification of hypoglycemic disorders.

Authors:  F J Service
Journal:  Endocrinol Metab Clin North Am       Date:  1999-09       Impact factor: 4.741

3.  Severe hypoglycemia caused by paraneoplastic production of IGF-II in patients with advanced gastrointestinal stromal tumors: a report of two cases.

Authors:  Daniel Pink; Dagmar Schoeler; Tanja Lindner; Peter C Thuss-Patience; Albrecht Kretzschmar; Heike Knipp; Udo Vanhoefer; Peter Reichardt
Journal:  J Clin Oncol       Date:  2005-09-20       Impact factor: 44.544

Review 4.  Role of insulin-like growth factor (IGF) II and IGF binding proteins in extrapancreatic tumour hypoglycaemia.

Authors:  J Zapf
Journal:  J Intern Med       Date:  1993-12       Impact factor: 8.989

Review 5.  Diagnostic approach to adults with hypoglycemic disorders.

Authors:  F J Service
Journal:  Endocrinol Metab Clin North Am       Date:  1999-09       Impact factor: 4.741

Review 6.  Hypoglycemia in patients with non-islet cell tumors.

Authors:  W H Daughaday
Journal:  Endocrinol Metab Clin North Am       Date:  1989-03       Impact factor: 4.741

7.  Severe hypoglycemia and hypokalemia in association with liver metastases of gastric cancer.

Authors:  Akihiko Kato; Etsuro Bando; Shingo Shinozaki; Yutaka Yonemura; Motohiko Aiba; Izumi Fukuda; Naomi Hizuka; Toru Kameya
Journal:  Intern Med       Date:  2004-09       Impact factor: 1.271

8.  High molecular weight form insulin-like growth factor II-producing mesenteric sarcoma causing hypoglycemia.

Authors:  Ryuji Sato; Motoyoshi Tsujino; Kenji Nishida; Yasukazu Otani; Tomohito Minami; Masayoshi Shichiri; Naomi Hizuka; Motohiko Aiba; Yukio Hitara
Journal:  Intern Med       Date:  2004-10       Impact factor: 1.271

9.  Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.

Authors:  W H Daughaday; M A Emanuele; M H Brooks; A L Barbato; M Kapadia; P Rotwein
Journal:  N Engl J Med       Date:  1988-12-01       Impact factor: 91.245

10.  "Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma.

Authors:  L Morbois-Trabut; F Maillot; A De Widerspach-Thor; F Lamisse; C Couet
Journal:  Diabetes Metab       Date:  2004-06       Impact factor: 6.041
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  2 in total

1.  Insulin-like growth factor II-producing metastatic colon cancer with recurrent hypoglycemia.

Authors:  Satoshi Teramae; Hiroshi Miyamoto; Naoki Muguruma; Yasuyuki Okada; Takahiro Goji; Shinji Kitamura; Tetsuo Kimura; Masako Kimura; Yoshimi Bando; Tetsuji Takayama
Journal:  Clin J Gastroenterol       Date:  2015-01-21

2.  Glucose metabolism disorders in cancer patients in a Chinese population.

Authors:  Ya-Shi Zhan; Lie Feng; Shao-Hui Tang; Wan-Geng Li; Meng Xu; Tian-Fu Liu; You-Fen Zhou; Yu-Lin Ma; Yun Zhang; Xian-Ming Pu
Journal:  Med Oncol       Date:  2009-03-05       Impact factor: 3.064
  2 in total

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