Literature DB >> 18350513

In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells.

Katarzyna Skupień1, Dorota Kostrzewa-Nowak, Jan Oszmiański, Jolanta Tarasiuk.   

Abstract

The aim of the present study was to determine in vitro antileukaemic activities of extracts obtained from chokeberry (Aronia melanocarpa [Michx] Elliot) and mulberry (Morus alba L.) leaves against promyelocytic HL60 cell line and its multidrug resistant sublines exhibiting two different MDR phenotypes: HL60/VINC (overexpressing P-glycoprotein) and HL60/DOX (overexpressing MRP1 protein). It was found that the extracts from chokeberry and mulberry leaves were active against the sensitive leukaemic cell line HL60 and retained the in vitro activity against multidrug resistant sublines (HL60/VINC and HL60/DOX). The values of resistance factor (RF) found for these extracts were very low lying in the range 1.2-1.6.

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Year:  2008        PMID： 18350513     DOI： 10.1002/ptr.2411

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  6 in total

1.  Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants.

Authors:  Christine Chichioco-Hernandez; Jakub Wudarski; Lieven Gevaert; Luc Verschaeve
Journal:  Pharmacogn Mag       Date:  2011-04       Impact factor: 1.085

2.  Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.

Authors:  Tanveer Sharif; Mahmoud Alhosin; Cyril Auger; Carole Minker; Jong-Hun Kim; Nelly Etienne-Selloum; Pierre Bories; Hinrich Gronemeyer; Annelise Lobstein; Christian Bronner; Guy Fuhrmann; Valérie B Schini-Kerth
Journal:  PLoS One       Date:  2012-03-08       Impact factor: 3.240

3.  Composition and Antibacterial Activity of Aronia melanocarpa (Michx.) Elliot, Cornus mas L. and Chaenomeles superba Lindl. Leaf Extracts.

Authors:  Magdalena Efenberger-Szmechtyk; Agnieszka Nowak; Agata Czyżowska; Alicja Z Kucharska; Izabela Fecka
Journal:  Molecules       Date:  2020-04-25       Impact factor: 4.411

Review 4.  Black Chokeberry Aronia melanocarpa L.-A Qualitative Composition, Phenolic Profile and Antioxidant Potential.

Authors:  Andrzej Sidor; Anna Gramza-Michałowska
Journal:  Molecules       Date:  2019-10-15       Impact factor: 4.411

Review 5.  Phenolic Composition, Mineral Content, and Beneficial Bioactivities of Leaf Extracts from Black Currant (Ribes nigrum L.), Raspberry (Rubus idaeus), and Aronia (Aronia melanocarpa).

Authors:  Monika Staszowska-Karkut; Małgorzata Materska
Journal:  Nutrients       Date:  2020-02-12       Impact factor: 5.717

6.  In vitro antioxidant capacities of eight different kinds of apples and their effects on lipopolysaccharide-induced oxidative damage in mice.

Authors:  Shuang Guo; Yuehua Wang; Shurui Chou; Huijun Cui; Dongnan Li; Bin Li
Journal:  PLoS One       Date:  2018-01-25       Impact factor: 3.240
  6 in total

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