OBJECTIVE: The lack of nocturnal decline in blood pressure (BP) is associated with an increase in cardiovascular events. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. The purpose of this study was to examine the relationship between vascular endothelial functions, carotid intima-media thickness (cIMT), plasma sCD40L levels and circadian BP profile in patients with essential hypertension. MATERIAL AND METHODS: The study population consisted of 81 essential hypertensive out-patients. BP dipping was defined as a night-to-day systolic and diastolic decrease >or=10%. Forty-seven dipper and 34 nondipper patients were compared. High sensitivity C-reactive protein (hs-CRP), sCD40L and urinary albumin were measured. Brachial artery flow-mediated dilatation (FMD) and cIMT was compared between the groups. RESULTS: sCD40L level (3.28 +/- 2.08 and 2.30 +/- 1.99 ng/ml, respectively, P = 0.036) and urinary albumin concentration (36.7 +/- 20.1 and 23 +/- 29.7 mg/l, respectively, P < 0.0001) were higher in nondippers than in dippers. Serum hs-CRP levels were not significantly different. FMD was found higher in dippers than nondippers (11.8 +/- 3.9% and 6.6 +/- 2.2%, respectively, P < 0.0001). The average cIMT was significantly higher in nondippers than dippers (0.928 +/- 0.060 Vs. 0.734 +/- 0.134 mm; P < 0.0001). CONCLUSIONS: Nondipper patern has an additional negative effect on endothelial functions in hypertensive patients. Nondippers have enhanced sCD40L levels, which may contribute to their increased susceptibility to develop vascular damage.
OBJECTIVE: The lack of nocturnal decline in blood pressure (BP) is associated with an increase in cardiovascular events. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. The purpose of this study was to examine the relationship between vascular endothelial functions, carotid intima-media thickness (cIMT), plasma sCD40L levels and circadian BP profile in patients with essential hypertension. MATERIAL AND METHODS: The study population consisted of 81 essential hypertensive out-patients. BP dipping was defined as a night-to-day systolic and diastolic decrease >or=10%. Forty-seven dipper and 34 nondipper patients were compared. High sensitivity C-reactive protein (hs-CRP), sCD40L and urinary albumin were measured. Brachial artery flow-mediated dilatation (FMD) and cIMT was compared between the groups. RESULTS: sCD40L level (3.28 +/- 2.08 and 2.30 +/- 1.99 ng/ml, respectively, P = 0.036) and urinary albumin concentration (36.7 +/- 20.1 and 23 +/- 29.7 mg/l, respectively, P < 0.0001) were higher in nondippers than in dippers. Serum hs-CRP levels were not significantly different. FMD was found higher in dippers than nondippers (11.8 +/- 3.9% and 6.6 +/- 2.2%, respectively, P < 0.0001). The average cIMT was significantly higher in nondippers than dippers (0.928 +/- 0.060 Vs. 0.734 +/- 0.134 mm; P < 0.0001). CONCLUSIONS: Nondipper patern has an additional negative effect on endothelial functions in hypertensivepatients. Nondippers have enhanced sCD40L levels, which may contribute to their increased susceptibility to develop vascular damage.
Authors: J A Staessen; L Thijs; R Fagard; E T O'Brien; D Clement; P W de Leeuw; G Mancia; C Nachev; P Palatini; G Parati; J Tuomilehto; J Webster Journal: JAMA Date: 1999-08-11 Impact factor: 56.272
Authors: S D Pierdomenico; D Lapenna; M D Guglielmi; F Costantini; F Romano; C Schiavone; F Cuccurullo; A Mezzetti Journal: Am J Hypertens Date: 1997-05 Impact factor: 2.689
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Authors: Eugene R Ahn; Gabriella Lander; Wenche Jy; Carlos J Bidot; Joaquin J Jimenez; Lawrence L Horstman; Yeon S Ahn Journal: Thromb Res Date: 2004 Impact factor: 3.944
Authors: Frederic F Rahbari-Oskoui; Dana C Miskulin; Marie C Hogan; Odicie Fielder; Vicente E Torres; James E Bost; Arlene Beth Chapman Journal: Blood Press Monit Date: 2011-04 Impact factor: 1.444
Authors: Olga Trojnarska; Ludwina Szczepaniak-Chicheł; Katarzyna Mizia-Stec; Marcin Gabriel; Agnieszka Bartczak; Stefan Grajek; Zbigniew Gąsior; Lucyna Kramer; Andrzej Tykarski Journal: Clin Res Cardiol Date: 2010-12-16 Impact factor: 5.460