| Literature DB >> 18346877 |
M Wenghoefer1, A Pantelis, H Dommisch, R Reich, M Martini, J-P Allam, N Novak, S Bergé, S Jepsen, J Winter.
Abstract
The aim of this study was to investigate the gene expression of human beta-defensin-1, -2, -3 (hBD-1, -2, -3), interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 in oral squamous cell carcinoma (OSCC) compared to benign and premalignant lesions as well as healthy controls. Biopsies of healthy gingiva (n=5), irritation fibroma (n=5), leukoplakia (n=5) and OSCC (n=5) were obtained during routine surgical procedures. RNA was extracted according to standard protocols and transcripts of hBD-1, -2, -3, interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 were analysed by real-time polymerase chain reaction. The expression of hBD-1 was reduced in all lesions (5-fold in irritation fibroma and 2.5-fold in leukoplakia), but most significantly (50-fold) in OSCC. hBD-1 appears to play a role in the development of OSCC. The loss of its function might contribute to the malignant progression of these tumours.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18346877 DOI： 10.1016/j.ijom.2008.02.003
Source DB: PubMed Journal: Int J Oral Maxillofac Surg ISSN： 0901-5027 Impact factor: 2.789