Literature DB >> 18346519

Decreased bone mineral density with off-label use of tenofovir in children and adolescents infected with human immunodeficiency virus.

Julia B Purdy1, Rachel I Gafni, James C Reynolds, Steven Zeichner, Rohan Hazra.   

Abstract

5 of 6 children infected with human immunodeficiency virus (HIV) receiving Tenofovir disoproxil fumarate (TDF) experienced absolute decreases in bone mineral density (BMD). 2 pre-pubertal subjects experienced >6% BMD decreases. 1 subject was the smallest child and experienced a 27% decrease, necessitating withdrawal of TDF. Subsequently, her BMD recovered. Monitoring of children infected with HIV who require treatment with TDF is warranted.

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Year:  2008        PMID： 18346519      PMCID： PMC2390888          DOI： 10.1016/j.jpeds.2007.12.020

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  7 in total

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Journal:  J Clin Endocrinol Metab       Date:  1999-12       Impact factor: 5.958

2.  A 12-month treatment with tenofovir does not impair bone mineral accrual in HIV-infected children.

Authors:  Vania Giacomet; Stefano Mora; Laura Martelli; Marzia Merlo; Mariateresa Sciannamblo; Alessandra Viganò
Journal:  J Acquir Immune Defic Syndr       Date:  2005-12-01       Impact factor: 3.731

3.  Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection.

Authors:  Rohan Hazra; Rachel I Gafni; Frank Maldarelli; Frank M Balis; Antonella N Tullio; Ellen DeCarlo; Carol J Worrell; Seth M Steinberg; John Flaherty; Kitty Yale; Brian P Kearney; Steven L Zeichner
Journal:  Pediatrics       Date:  2005-11-15       Impact factor: 7.124

4.  Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children.

Authors:  Rachel I Gafni; Rohan Hazra; James C Reynolds; Frank Maldarelli; Antonella N Tullio; Ellen DeCarlo; Carol J Worrell; John F Flaherty; Kitty Yale; Brian P Kearney; Steven L Zeichner
Journal:  Pediatrics       Date:  2006-08-21       Impact factor: 7.124

5.  National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification.

Authors:  Ronald J Hogg; Susan Furth; Kevin V Lemley; Ronald Portman; George J Schwartz; Josef Coresh; Ethan Balk; Joseph Lau; Adeera Levin; Annamaria T Kausz; Garabed Eknoyan; Andrew S Levey
Journal:  Pediatrics       Date:  2003-06       Impact factor: 7.124

6.  Bone densitometry in Canadian children 8-17 years of Age.

Authors:  R A Faulkner; D A Bailey; D T Drinkwater; H A McKay; C Arnold; A A Wilkinson
Journal:  Calcif Tissue Int       Date:  1996-11       Impact factor: 4.333

7.  Single-dose and steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected children.

Authors:  Rohan Hazra; Frank M Balis; Antonella N Tullio; Ellen DeCarlo; Carol J Worrell; Seth M Steinberg; John F Flaherty; Kitty Yale; Marianne Poblenz; Brian P Kearney; Lijie Zhong; Dion F Coakley; Stephane Blanche; Jean Louis Bresson; Judith A Zuckerman; Steven L Zeichner
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191
  7 in total
  47 in total

Review 1.  Hepatitis B therapy.

Authors:  Hellan Kwon; Anna S Lok
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2011-03-22       Impact factor: 46.802

2.  Tenofovir treatment of primary osteoblasts alters gene expression profiles: implications for bone mineral density loss.

Authors:  Iwen F Grigsby; Lan Pham; Louis M Mansky; Raj Gopalakrishnan; Ann E Carlson; Kim C Mansky
Journal:  Biochem Biophys Res Commun       Date:  2010-02-18       Impact factor: 3.575

3.  Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life.

Authors:  A Bamford; A Turkova; H Lyall; C Foster; N Klein; D Bastiaans; D Burger; S Bernadi; K Butler; E Chiappini; P Clayden; M Della Negra; V Giacomet; C Giaquinto; D Gibb; L Galli; M Hainaut; M Koros; L Marques; E Nastouli; T Niehues; A Noguera-Julian; P Rojo; C Rudin; H J Scherpbier; G Tudor-Williams; S B Welch
Journal:  HIV Med       Date:  2015-02-03       Impact factor: 3.180

4.  Bone alterations associated with HIV.

Authors:  Amy H Warriner; Michael Mugavero; E Turner Overton
Journal:  Curr HIV/AIDS Rep       Date:  2014-09       Impact factor: 5.071

Review 5.  Antiretroviral therapy for children in resource-limited settings: current regimens and the role of newer agents.

Authors:  Brian S Eley; Tammy Meyers
Journal:  Paediatr Drugs       Date:  2011-10-01       Impact factor: 3.022

6.  Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection.

Authors:  Mustafa Kemal Celen; Duygu Mert; Müzeyyen Ay; Tuba Dal; Safak Kaya; Necmettin Yildirim; Serda Gulsun; Tunga Barcin; Sevgi Kalkanli; Mehmet Sinan Dal; Celal Ayaz
Journal:  World J Gastroenterol       Date:  2013-12-28       Impact factor: 5.742

Review 7.  Update on tenofovir toxicity in the kidney.

Authors:  Andrew M Hall
Journal:  Pediatr Nephrol       Date:  2012-08-10       Impact factor: 3.714

Review 8.  Pharmacokinetic optimization of antiretroviral therapy in children and adolescents.

Authors:  Michael N Neely; Natella Y Rakhmanina
Journal:  Clin Pharmacokinet       Date:  2011-03       Impact factor: 6.447

9.  Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts.

Authors:  Iwen F Grigsby; Lan Pham; Raj Gopalakrishnan; Louis M Mansky; Kim C Mansky
Journal:  Biochem Biophys Res Commun       Date:  2009-12-21       Impact factor: 3.575

10.  Bone mineral density in children and adolescents with perinatal HIV infection.

Authors:  Linda A DiMeglio; JiaJia Wang; George K Siberry; Tracie L Miller; Mitchell E Geffner; Rohan Hazra; William Borkowsky; Janet S Chen; Laurie Dooley; Kunjal Patel; Russell B van Dyke; Roger A Fielding; Yared Gurmu; Denise L Jacobson
Journal:  AIDS       Date:  2013-01-14       Impact factor: 4.177
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