Literature DB >> 1834641

Human interferon omega (omega) binds to the alpha/beta receptor.

I Flores1, T M Mariano, S Pestka.   

Abstract

It was proposed that human interferon omega (omega) binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. However, since no studies were performed to provide direct evidence for this hypothesis, we carried out cross-linking experiments and saturation binding assays between a 32P-labeled human interferon-alpha (Hu-IFN-alpha) and unlabeled Hu-IFN-alpha A, -beta, -gamma, and -omega. These assays demonstrated that Hu-IFN-alpha A, -beta, and -omega, but not Hu-IFN-gamma, were able to block binding of 32P-labeled Hu-IFN-alpha A to human cells. These results indicate that Hu-IFN-omega binds to the alpha/beta receptor.

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Year:  1991        PMID： 1834641

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

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Authors:  S V Kotenko; L S Izotova; O V Mirochnitchenko; C Lee; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Structural analysis of the human interferon gamma receptor: a small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity.

Authors:  J R Cook; V Jung; B Schwartz; P Wang; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

3.  Antiviral activities of the soluble extracellular domains of type I interferon receptors.

Authors:  C S Han; Y Chen; T Ezashi; R M Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-08       Impact factor: 11.205

4.  Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice.

Authors:  X Q Qin; N Tao; A Dergay; P Moy; S Fawell; A Davis; J M Wilson; J Barsoum
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

5.  Phosphorylation of the purified cardiac ryanodine receptor by exogenous and endogenous protein kinases.

Authors:  M Hohenegger; J Suko
Journal:  Biochem J       Date:  1993-12-01       Impact factor: 3.857

6.  Effects of type I-interferons on human thyroid epithelial cells derived from normal and tumour tissue.

Authors:  E Selzer; A Wilfing; V Sexl; M Freissmuth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-09       Impact factor: 3.000

Review 7.  Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease.

Authors:  Lindsey E Fox; Marissa C Locke; Deborah J Lenschow
Journal:  Front Immunol       Date:  2020-12-21       Impact factor: 7.561

Review 8.  The Swine IFN System in Viral Infections: Major Advances and Translational Prospects.

Authors:  Elisabetta Razzuoli; Federico Armando; Livia De Paolis; Malgorzata Ciurkiewicz; Massimo Amadori
Journal:  Pathogens       Date:  2022-01-27

Review 9.  Impact of genetic polymorphisms related to innate immune response on respiratory syncytial virus infection in children.

Authors:  Laura Elena Córdova-Dávalos; Alicia Hernández-Mercado; Claudia Berenice Barrón-García; Augusto Rojas-Martínez; Mariela Jiménez; Eva Salinas; Daniel Cervantes-García
Journal:  Virus Genes       Date:  2022-09-09       Impact factor: 2.198

10.  Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.

Authors:  C Abramovich; L M Shulman; E Ratovitski; S Harroch; M Tovey; P Eid; M Revel
Journal:  EMBO J       Date:  1994-12-15       Impact factor: 11.598
  10 in total

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