Literature DB >> 18345678

Therapeutic target metabolism observed using hyperpolarized 15N choline.

Cristina Gabellieri1, Steven Reynolds, Arnon Lavie, Geoffrey S Payne, Martin O Leach, Thomas R Eykyn.   

Abstract

Choline is a precursor of cellular phospholipid metabolism that provides Magnetic Resonance (MR) and Positron Emission Tomography (PET) biomarkers for cancer detection and response assessment. Employing Dynamic Nuclear Polarization we show that the MR signal of 15N in choline can be enhanced by at least 4 orders of magnitude with a relaxation time of ca. 4 min, providing a method to observe the action of choline kinase, an important target for novel cancer therapeutics.

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Year:  2008        PMID： 18345678     DOI： 10.1021/ja8001293

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  46 in total

1.  Toward hyperpolarized molecular imaging of HIV: synthesis and longitudinal relaxation properties of (15) N-Azidothymidine.

Authors:  Roman V Shchepin; Eduard Y Chekmenev
Journal:  J Labelled Comp Radiopharm       Date:  2014-08-25       Impact factor: 1.921

2.  A versatile synthetic route to the preparation of 15 N heterocycles.

Authors:  Nikita V Chukanov; Bryce E Kidd; Larisa M Kovtunova; Valerii I Bukhtiyarov; Roman V Shchepin; Eduard Y Chekmenev; Boyd M Goodson; Kirill V Kovtunov; Igor V Koptyug
Journal:  J Labelled Comp Radiopharm       Date:  2019-01-07       Impact factor: 1.921

Review 3.  Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy.

Authors:  Siver Andreas Moestue; Olav Engebraaten; Ingrid Susann Gribbestad
Journal:  Mol Oncol       Date:  2011-04-23       Impact factor: 6.603

4.  Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

Authors:  John Kurhanewicz; Daniel B Vigneron; Kevin Brindle; Eduard Y Chekmenev; Arnaud Comment; Charles H Cunningham; Ralph J Deberardinis; Gary G Green; Martin O Leach; Sunder S Rajan; Rahim R Rizi; Brian D Ross; Warren S Warren; Craig R Malloy
Journal:  Neoplasia       Date:  2011-02       Impact factor: 5.715

5.  Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI.

Authors:  Peder E Z Larson; Robert Bok; Adam B Kerr; Michael Lustig; Simon Hu; Albert P Chen; Sarah J Nelson; John M Pauly; John Kurhanewicz; Daniel B Vigneron
Journal:  Magn Reson Med       Date:  2010-03       Impact factor: 4.668

6.  Direct inhibition of choline kinase by a near-infrared fluorescent carbocyanine.

Authors:  Sean P Arlauckas; Anatoliy V Popov; Edward J Delikatny
Journal:  Mol Cancer Ther       Date:  2014-07-15       Impact factor: 6.261

7.  Molecular imaging without radiopharmaceuticals?

Authors:  John C Gore; Thomas E Yankeelov; Todd E Peterson; Malcolm J Avison
Journal:  J Nucl Med       Date:  2009-05-14       Impact factor: 10.057

8.  A New Horizon of DNP technology: Application to In-vivo 13C Magnetic Resonance Spectroscopy and Imaging.

Authors:  Prasanta Dutta; Gary V Martinez; Robert J Gillies
Journal:  Biophys Rev       Date:  2013-01-09

9.  Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy.

Authors:  Richard G Abramson; Lori R Arlinghaus; Jared A Weis; Xia Li; Adrienne N Dula; Eduard Y Chekmenev; Seth A Smith; Michael I Miga; Vandana G Abramson; Thomas E Yankeelov
Journal:  Breast Cancer (Dove Med Press)       Date:  2012-10

Review 10.  Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

Authors:  Kayvan R Keshari; David M Wilson
Journal:  Chem Soc Rev       Date:  2013-12-20       Impact factor: 54.564
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