Literature DB >> 18344517

GlycoBase and autoGU: tools for HPLC-based glycan analysis.

Matthew P Campbell1, Louise Royle, Catherine M Radcliffe, Raymond A Dwek, Pauline M Rudd.   

Abstract

SUMMARY: The development of robust high-performance liquid chromatography (HPLC) technologies continues to improve the detailed analysis and sequencing of glycan structures released from glycoproteins. Here, we present a database (GlycoBase) and analytical tool (autoGU) to assist the interpretation and assignment of HPLC-glycan profiles. GlycoBase is a relational database which contains the HPLC elution positions for over 350 2-AB labelled N-glycan structures together with predicted products of exoglycosidase digestions. AutoGU assigns provisional structures to each integrated HPLC peak and, when used in combination with exoglycosidase digestions, progressively assigns each structure automatically based on the footprint data. These tools are potentially very promising and facilitate basic research as well as the quantitative high-throughput analysis of low concentrations of glycans released from glycoproteins. AVAILABILITY: http://glycobase.ucd.ie

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Year:  2008        PMID： 18344517     DOI： 10.1093/bioinformatics/btn090

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


  76 in total

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7.  Building a PGC-LC-MS N-glycan retention library and elution mapping resource.

Authors:  Jodie L Abrahams; Matthew P Campbell; Nicolle H Packer
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8.  Isomer-specific LC/MS and LC/MS/MS profiling of the mouse serum N-glycome revealing a number of novel sialylated N-glycans.

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9.  GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources.

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Review 10.  Bioinformatics and molecular modeling in glycobiology.

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