Literature DB >> 18343886

Shortening of cardiac action potential duration near an insulating boundary.

John W Cain1, David G Schaeffer.   

Abstract

It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre. An asymptotic approximation for the dependence of action potential duration on distance to the boundary is derived. This estimate agrees well with simulations.

Mesh:

Year:  2008        PMID: 18343886      PMCID: PMC2447675          DOI: 10.1093/imammb/dqn002

Source DB:  PubMed          Journal:  Math Med Biol        ISSN: 1477-8599            Impact factor:   1.854


  6 in total

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  6 in total
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  3 in total

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