Literature DB >> 18343662

Meclonazepam analogues as potential new antihelmintic agents.

Aman Mahajan1, Vipan Kumar, Nuha R N Mansour, Quentin Bickle, Kelly Chibale.   

Abstract

New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni.

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Year:  2008        PMID： 18343662     DOI： 10.1016/j.bmcl.2008.02.077

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules.

Authors:  Kimberley M Zorn; Shengxi Sun; Cecelia L McConnon; Kelley Ma; Eric K Chen; Daniel H Foil; Thomas R Lane; Lawrence J Liu; Nelly El-Sakkary; Danielle E Skinner; Sean Ekins; Conor R Caffrey
Journal:  ACS Infect Dis       Date:  2021-01-12       Impact factor: 5.084

Review 2.  Experimentally promising antischistosomal drugs: a review of some drug candidates not reaching the clinical use.

Authors:  Rashad A Abdul-Ghani; Naguiba Loutfy; Azza Hassan
Journal:  Parasitol Res       Date:  2009-07-09       Impact factor: 2.289

3.  Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni.

Authors:  Vanessa Dufour; Robin N Beech; Claudia Wever; Joseph A Dent; Timothy G Geary
Journal:  PLoS Pathog       Date:  2013-08-29       Impact factor: 6.823
  3 in total

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