Literature DB >> 18342381

A phase I-B trial of the radiosensitizer: etanidazole (SR-2508) with radiosurgery for the treatment of recurrent previously irradiated primary brain tumors or brain metastases (RTOG Study 95-02).

R E Drzymala1, T H Wasserman, M Won, E Shaw, A J Cmelak, J Loeffler, L Souhami.   

Abstract

RTOG 95-02 assessed patient tolerance to hypoxic cell radiosensitizer, etanidazole (SR-2508), combined with radiosurgery. Patients had primary or metastatic brain tumors and previously localized or whole brain irradiation. The toxicity is reported in three groups of patients according to the tumor size. Etanidazole doses of 12g/m2 combined with radiosurgery were well tolerated.

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Year:  2008        PMID: 18342381     DOI: 10.1016/j.radonc.2008.02.006

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN: 0167-8140            Impact factor:   6.280


  6 in total

1.  Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia.

Authors:  David J Carlson; Paul J Keall; Billy W Loo; Zhe J Chen; J Martin Brown
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-12-22       Impact factor: 7.038

2.  Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer.

Authors:  J Martin Brown; Maximilian Diehn; Billy W Loo
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-10-01       Impact factor: 7.038

3.  Stereotactic radiosurgery: a meta-analysis of current therapeutic applications in neuro-oncologic disease.

Authors:  Susan C Pannullo; Justin F Fraser; Jennifer Moliterno; William Cobb; Philip E Stieg
Journal:  J Neurooncol       Date:  2010-12-09       Impact factor: 4.130

4.  Correlation of hypoxia status with radiosensitizing effects of sodium glycididazole: A preclinical study.

Authors:  Yang Yu; Xiaolin Li; Hengwei Xu; Jing Liu; Min Dong; Jia Yang; Lu Sun; Xiaorong Sun; Ligang Xing
Journal:  Oncol Lett       Date:  2018-02-21       Impact factor: 2.967

5.  High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors.

Authors:  Olivia J Kelada; Roy H Decker; Sameer K Nath; Kimberly L Johung; Ming-Qiang Zheng; Yiyun Huang; Jean-Dominique Gallezot; Chi Liu; Richard E Carson; Uwe Oelfke; David J Carlson
Journal:  Int J Radiat Oncol Biol Phys       Date:  2018-06-01       Impact factor: 7.038

6.  A fast radiotherapy paradigm for anal cancer with volumetric modulated arc therapy (VMAT).

Authors:  Florian Stieler; Dirk Wolff; Frank Lohr; Volker Steil; Yasser Abo-Madyan; Friedlieb Lorenz; Frederik Wenz; Sabine Mai
Journal:  Radiat Oncol       Date:  2009-10-25       Impact factor: 3.481

  6 in total

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