OBJECTIVES: To investigate the relationship between admission glycaemic status and inpatient mortality in patients with and without pre-existing diabetes. DESIGN: Prospective observational cohort study. SETTING: A general medical ward in an Australian tertiary referral hospital. PARTICIPANTS: 903 patients admitted to the general medical ward between February 2003 and July 2004. MAIN OUTCOME MEASURE: Inpatient death. RESULTS: The overall inpatient mortality was 5.4% (n = 49). In the total cohort, age > 75 years and admission fasting plasma glucose (FPG) levels > or = 5.6 mmol/L were independent predictors of mortality. For patients without a known history of diabetes, each 1 mmol/L rise in admission FPG was associated with a 33% increase in mortality. In these patients, elevated (> 6.0%) and normal glycated haemoglobin (HbA(1c)) levels were associated with mortalities of 11.3% and 4.4%, respectively (odds ratio, 2.47; 95% CI, 1.16-5.26). In contrast, in patients with known diabetes, there was no association between admission FPG levels, HbA(1c) and mortality. Length of stay was not independently associated with FPG, HbA(1c), or diabetes status. CONCLUSIONS: In patients without known diabetes, the risk of death was increased for admission FPG levels > or = 5.6 mmol/L. However, pre-existing abnormal glucose metabolism, reflected by elevated HbA(1c) levels, appeared a more important predictor of inpatient mortality than glucose levels in patients without known diabetes.
OBJECTIVES: To investigate the relationship between admission glycaemic status and inpatient mortality in patients with and without pre-existing diabetes. DESIGN: Prospective observational cohort study. SETTING: A general medical ward in an Australian tertiary referral hospital. PARTICIPANTS: 903 patients admitted to the general medical ward between February 2003 and July 2004. MAIN OUTCOME MEASURE: Inpatient death. RESULTS: The overall inpatient mortality was 5.4% (n = 49). In the total cohort, age > 75 years and admission fasting plasma glucose (FPG) levels > or = 5.6 mmol/L were independent predictors of mortality. For patients without a known history of diabetes, each 1 mmol/L rise in admission FPG was associated with a 33% increase in mortality. In these patients, elevated (> 6.0%) and normal glycated haemoglobin (HbA(1c)) levels were associated with mortalities of 11.3% and 4.4%, respectively (odds ratio, 2.47; 95% CI, 1.16-5.26). In contrast, in patients with known diabetes, there was no association between admission FPG levels, HbA(1c) and mortality. Length of stay was not independently associated with FPG, HbA(1c), or diabetes status. CONCLUSIONS: In patients without known diabetes, the risk of death was increased for admission FPG levels > or = 5.6 mmol/L. However, pre-existing abnormal glucose metabolism, reflected by elevated HbA(1c) levels, appeared a more important predictor of inpatient mortality than glucose levels in patients without known diabetes.
Authors: L Lapointe-Shaw; T Voruganti; P Kohler; H-H Thein; B Sander; A McGeer Journal: Eur J Clin Microbiol Infect Dis Date: 2017-01-11 Impact factor: 3.267
Authors: Natalie Nanayakkara; Hang Nguyen; Leonid Churilov; Alvin Kong; Nyuk Pang; Graeme K Hart; Elizabeth Owen-Jones; Jennifer White; Jane Ross; Victoria Stevenson; Rinaldo Bellomo; Que Lam; Nicholas Crinis; Raymond Robbins; Doug Johnson; Scott T Baker; Jeffrey D Zajac; Elif I Ekinci Journal: BMJ Open Diabetes Res Care Date: 2015-09-07