CONCLUSION: Tumors developing into the muscle layer and tumor thickness > or =5 mm are the most important risk factors associated with nodal metastasis. OBJECTIVE: It is necessary to identify the risk factors associated with cervical metastasis in patients with oral floor cancer to reveal the role of elective neck dissection for oral floor cancer. PATIENTS AND METHODS: Forty-eight patients with oral floor cancer were retrospectively analyzed for a correlation between clinicopathologic factors and cervical lymph node metastasis using Fisher's exact test and a logistic regression test. RESULTS: Univariate analysis showed significantly positive correlations for growth type, mitosis, perineural invasion, vascular invasion, lymphatic invasion, depth, thickness, and infiltration growth ratio. Multivariate analysis had a significantly positive correlation with nest formation and depth in all patients, and with thickness in patients with T1 or T2. In patients with bilateral cervical lymph node metastasis, lymph node metastasis was significantly positively correlated with perineural invasion.
CONCLUSION: Tumors developing into the muscle layer and tumor thickness > or =5 mm are the most important risk factors associated with nodal metastasis. OBJECTIVE: It is necessary to identify the risk factors associated with cervical metastasis in patients with oral floor cancer to reveal the role of elective neck dissection for oral floor cancer. PATIENTS AND METHODS: Forty-eight patients with oral floor cancer were retrospectively analyzed for a correlation between clinicopathologic factors and cervical lymph node metastasis using Fisher's exact test and a logistic regression test. RESULTS: Univariate analysis showed significantly positive correlations for growth type, mitosis, perineural invasion, vascular invasion, lymphatic invasion, depth, thickness, and infiltration growth ratio. Multivariate analysis had a significantly positive correlation with nest formation and depth in all patients, and with thickness in patients with T1 or T2. In patients with bilateral cervical lymph node metastasis, lymph node metastasis was significantly positively correlated with perineural invasion.
Authors: Magdy E Mahfouz; Juan P Rodrigo; Robert P Takes; Mohamed N Elsheikh; Alessandra Rinaldo; Ruud H Brakenhoff; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2010-06 Impact factor: 2.503
Authors: F Arias; V Chicata; M J García-Velloso; G Asín; M Uzcanga; C Eito; I Quilez; A Viudez; J Saenz; I Hernández; C Caicedo; M Errasti; M Barrado; F García-Bragado Journal: Clin Transl Oncol Date: 2014-07-31 Impact factor: 3.405
Authors: Wouter L Lodder; Hendrik J Teertstra; Ing B Tan; Frank A Pameijer; Ludi E Smeele; Marie-Louise F van Velthuysen; Michiel W M van den Brekel Journal: Eur Radiol Date: 2010-08-03 Impact factor: 5.315
Authors: Josena K Stephen; Kang Mei Chen; Veena Shah; Shaleta Havard; Alissa Kapke; Mei Lu; Michael S Benninger; Maria J Worsham Journal: Clin Epigenetics Date: 2010-09-01 Impact factor: 6.551