| Literature DB >> 18339298 |
Laurent Guillemot1, Serge Paschoud, Pamela Pulimeno, Andrea Foglia, Sandra Citi.
Abstract
The region of cytoplasm underlying the tight junction (TJ) contains several multimolecular protein complexes, which are involved in scaffolding of membrane proteins, regulation of cytoskeletal organization, establishment of polarity, and signalling to and from the nucleus. In this review, we summarize some of the most recent advances in understanding the identity of these proteins, their domain organization, their protein interactions, and their functions in vertebrate organisms. Analysis of knockdown and knockout model systems shows that several TJ proteins are essential for the formation of epithelial tissues and early embryonic development, whereas others appear to have redundant functions.Mesh：
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Year: 2007 PMID： 18339298 DOI： 10.1016/j.bbamem.2007.09.032
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002