Literature DB >> 18338049

One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of alpha-bromoacetate, malononitrile and aromatic aldehydes.

Chao Guo Yan1, Xiao Kai Song, Qi Fang Wang, Jing Sun, Ulrich Siemeling, Clemens Bruhn.   

Abstract

Polysubstituted benzene derivatives with an unprecedented substitution pattern are produced in a novel one-pot multi-component cyclization reaction from pyridine, ethyl alpha-bromoacetate, malononitrile and aromatic aldehyde in refluxing acetonitrile.

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Year:  2008        PMID： 18338049     DOI： 10.1039/b718171j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Convenient synthesis of polyfunctional dihydrothiophenes with tandem reaction of 1,3-thiazolidinedione, aldehyde, arylamine and ethyl cyanoacetate.

Authors:  Jing Sun; Er-Yan Xia; Rong Yao; Chao-Guo Yan
Journal:  Mol Divers       Date:  2010-09-17       Impact factor: 2.943

2.  Synthesis of 6a,6b,13,13a-tetrahydro-6H-5-oxa-12a-azadibenzo[a,g]fluorene derivatives via cycloaddition reactions of isoquinolinium salts with 3-nitrochromenes.

Authors:  Jun Fang; Chao-Guo Yan
Journal:  Mol Divers       Date:  2013-10-22       Impact factor: 2.943

3.  Organobase-catalyzed three-component reactions for the synthesis of 4H-2-aminopyrans, condensed pyrans and polysubstituted benzenes.

Authors:  Moustafa Sherief Moustafa; Saleh Mohammed Al-Mousawi; Maghraby Ali Selim; Ahmed Mohamed Mosallam; Mohamed Hilmy Elnagdi
Journal:  Beilstein J Org Chem       Date:  2014-01-14       Impact factor: 2.883

4.  Stepwise cycloaddition reaction of N-phenacylbenzothiazolium bromides and nitroalkenes for tetrahydro-, dihydro- and benzo[d]pyrrolo[2,1-b]thiazoles.

Authors:  Gong Jin; Jing Sun; Ren-Yin Yang; Chao-Guo Yan
Journal:  Sci Rep       Date:  2017-04-13       Impact factor: 4.379

5.  Formation of diverse polycyclic spirooxindoles via three-component reaction of isoquinolinium salts, isatins and malononitrile.

Authors:  Jing Sun; Guo-Liang Shen; Ying Huang; Chao-Guo Yan
Journal:  Sci Rep       Date:  2017-01-20       Impact factor: 4.379

6.  Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction.

Authors:  Qin Fu; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2013-05-13       Impact factor: 2.883
  6 in total

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