Literature DB >> 18337333

Could neurocysticercosis be the cause of "onchocerciasis-associated" epileptic seizures?

Moses Katabarwa1, Tom Lakwo, Peace Habumogisha, Frank Richards, Mark Eberhard.   

Abstract

We conducted a nodule prevalence survey in four onchocerciasis sentinel communities in Moyo and two in Kanungu districts of Uganda. Seven (33.3%) out of 21 excised "onchocercomas" (nodules) in Moyo District and excised onchocercomas from four of six persons in Kanungu District turned out to be cysts of Taenia solium. We concluded that the prediction of nodule prevalence for noninvasive rapid epidemiologic assessment (REA) to target areas for mass chemotherapy with ivermectin in the African Program for Onchocerciasis Control (APOC) supported areas may have been influenced by other pathologies. T. solium infection may be the main cause of "onchocerciasis-associated epileptic seizures" in many onchocerciasis endemic communities that have been causally linked to onchocerciasis. Lastly, widespread neurocysticercosis may be a concern in mass treatment programs that provide praziquantel (for managing schistosomiasis) or albendazole (for managing intestinal worms or lymphatic filariasis) because these drugs may kill cerebral cysticerci, resulting in severe adverse events.

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Year:  2008        PMID: 18337333

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   2.345


  14 in total

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Authors:  C Waiswa; E M Fèvre; Z Nsadha; C S Sikasunge; A L Willingham
Journal:  J Parasitol Res       Date:  2009-06-28

Review 2.  Do helminths cause epilepsy?

Authors:  R G Wagner; C R Newton
Journal:  Parasite Immunol       Date:  2009-11       Impact factor: 2.280

Review 3.  Neurocysticercosis in sub-Saharan Africa: a review of prevalence, clinical characteristics, diagnosis, and management.

Authors:  Andrea Sylvia Winkler
Journal:  Pathog Glob Health       Date:  2012-09       Impact factor: 2.894

Review 4.  Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.

Authors:  Christoph Kaiser; Sébastien D S Pion; Michel Boussinesq
Journal:  PLoS Negl Trop Dis       Date:  2013-03-28

5.  Transmission of onchocerciasis in wadelai focus of northwestern Uganda has been interrupted and the disease eliminated.

Authors:  Moses N Katabarwa; Frank Walsh; Peace Habomugisha; Thomson L Lakwo; Stella Agunyo; David W Oguttu; Thomas R Unnasch; Dickson Unoba; Edson Byamukama; Ephraim Tukesiga; Richard Ndyomugyenyi; Frank O Richards
Journal:  J Parasitol Res       Date:  2012-08-26

6.  Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa.

Authors:  Uffe Christian Braae; Christopher F L Saarnak; Samson Mukaratirwa; Brecht Devleesschauwer; Pascal Magnussen; Maria Vang Johansen
Journal:  Parasit Vectors       Date:  2015-06-12       Impact factor: 3.876

7.  Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden.

Authors:  Peter J Hotez; Aruna Kamath
Journal:  PLoS Negl Trop Dis       Date:  2009-08-25

Review 8.  Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys.

Authors:  Sébastien D S Pion; Christoph Kaiser; Fernand Boutros-Toni; Amandine Cournil; Melanie M Taylor; Stefanie E O Meredith; Ansgar Stufe; Ione Bertocchi; Walter Kipp; Pierre-Marie Preux; Michel Boussinesq
Journal:  PLoS Negl Trop Dis       Date:  2009-06-16

9.  Nodding syndrome.

Authors:  Scott F Dowell; James J Sejvar; Lul Riek; Katelijn A H Vandemaele; Margaret Lamunu; Annette C Kuesel; Erich Schmutzhard; William Matuja; Sudhir Bunga; Jennifer Foltz; Thomas B Nutman; Andrea S Winkler; Anthony K Mbonye
Journal:  Emerg Infect Dis       Date:  2013       Impact factor: 6.883

10.  Prevalence of porcine cysticercosis in the Lake Kyoga Basin, Uganda.

Authors:  Zachary Nsadha; Lian F Thomas; Eric M Fèvre; George Nasinyama; Lonzy Ojok; Charles Waiswa
Journal:  BMC Vet Res       Date:  2014-10-05       Impact factor: 2.741

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