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Literature DB >> 18336350

Host defense peptides and the new line of defence against multiresistant infections.

Tobias Hirsch¹, Frank Jacobsen, Hans-Ulrich Steinau, Lars Steinstraesser.

Abstract

Increasing antibiotic resistance has led to an urgent need for new therapeutic approaches. Host defense peptides are known to be antimicrobial and have revealed broad immunomodulatory functions for both innate and adaptive immunity. This review will focus on the role of host defense peptides in infection and immune response and discuss its potential and limitations as a future therapeutical agent.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18336350 DOI： 10.2174/092986608783744252

Source DB: PubMed Journal: Protein Pept Lett ISSN： 0929-8665 Impact factor: 1.890

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Cited

13 in total

1. Bioengineered human skin: working the bugs out.

Authors: L Steinstraesser; S Al-Benna; M Kesting; F Jacobsen
Journal: Mol Ther Date: 2009-03 Impact factor: 11.454

2. Innate defense regulator peptide 1018 in wound healing and wound infection.

Authors: Lars Steinstraesser; Tobias Hirsch; Matthias Schulte; Maximilian Kueckelhaus; Frank Jacobsen; Evgenija A Mersch; Ingo Stricker; Nicole Afacan; Havard Jenssen; Robert E W Hancock; Jason Kindrachuk
Journal: PLoS One Date: 2012-08-06 Impact factor: 3.240

3. Structure-activity studies and therapeutic potential of host defense peptides of human thrombin.

Authors: Gopinath Kasetty; Praveen Papareddy; Martina Kalle; Victoria Rydengård; Matthias Mörgelin; Barbara Albiger; Martin Malmsten; Artur Schmidtchen
Journal: Antimicrob Agents Chemother Date: 2011-03-14 Impact factor: 5.191

4. Sequence inversion and phenylalanine surrogates at the beta-turn enhance the antibiotic activity of gramicidin S.

Authors: Concepción Solanas; Beatriz G de la Torre; María Fernández-Reyes; Clara M Santiveri; M Angeles Jiménez; Luis Rivas; Ana I Jiménez; David Andreu; Carlos Cativiela
Journal: J Med Chem Date: 2010-05-27 Impact factor: 7.446

5. Activity of the antimicrobial peptide and thanatin analog S-thanatin on clinical isolates of Klebsiella pneumoniae resistant to conventional antibiotics with different structures.

Authors: Guo-Qiu Wu; Jia-Xuan Ding; Lin-Xian Li; Hai-Liang Wang; Rui Zhao; Zi-Long Shen
Journal: Curr Microbiol Date: 2009-05-21 Impact factor: 2.188

Host defense peptides and the new line of defence against multiresistant infections.

1. Bioengineered human skin: working the bugs out.

2. Innate defense regulator peptide 1018 in wound healing and wound infection.

3. Structure-activity studies and therapeutic potential of host defense peptides of human thrombin.

4. Sequence inversion and phenylalanine surrogates at the beta-turn enhance the antibiotic activity of gramicidin S.

5. Activity of the antimicrobial peptide and thanatin analog S-thanatin on clinical isolates of Klebsiella pneumoniae resistant to conventional antibiotics with different structures.

6. Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn.

7. Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation.

Review 8. Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?

9. Integrating "omics" Technologies to Conceptualize Dynamic Antimicrobial Peptide Responses.

Review 10. Direct and indirect antimicrobial activities of neuropeptides and their therapeutic potential.