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Literature DB >> 18336038

Diastereoselective syntheses of chroman spiroketals via [4 + 2] cycloaddition of enol ethers and o-quinone methides.

Maurice A Marsini¹, Yaodong Huang, Christopher C Lindsey, Kun-Liang Wu, Thomas R R Pettus.

Abstract

A variety of chroman spiroketals are synthesized via inverse-demand [4 + 2] cycloaddition of enol ethers and ortho-quinone methides (o-QMs). Low temperature o-QM generation in situ allows for the kinetic, diastereoselective construction of these motifs, providing entry to a number of unusual chroman spiroketal natural products.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18336038 PMCID： PMC2430732 DOI： 10.1021/ol8003244

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

13 in total

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