Literature DB >> 18335312

Localization of the extracellular matrix protein SC1 coincides with synaptogenesis during rat postnatal development.

Starlee Lively1, Ian R Brown.   

Abstract

SC1 is an extracellular matrix protein that belongs to the SPARC family of matricellular molecules. This anti-adhesive protein localizes to synapses in the adult rat brain and has been postulated to modulate synapse shape. In this study, increased levels of SC1 were detected from postnatal days 10-20, with a peak at postnatal day 15, a period of intense synaptogenesis. During this time, increased colocalization of SC1 with the synaptic marker synaptophysin was observed in synapse-rich regions of the cerebellum and the cerebral cortex. These findings indicate that the pattern of SC1 localization coincided with synaptogenesis during rat postnatal development.

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Year:  2008        PMID: 18335312     DOI: 10.1007/s11064-008-9606-z

Source DB:  PubMed          Journal:  Neurochem Res        ISSN: 0364-3190            Impact factor:   3.996


  28 in total

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Journal:  Genome Res       Date:  1996-11       Impact factor: 9.043

5.  Extracellular matrix-associated protein Sc1 is not essential for mouse development.

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Authors:  M Del Cerro; J R Swarz
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Review 10.  Interactions between Purkinje neurones and Bergmann glia.

Authors:  Tomas C Bellamy
Journal:  Cerebellum       Date:  2006       Impact factor: 3.847

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  12 in total

1.  The extracellular matrix protein SC1/Hevin localizes to multivesicular bodies in Bergmann glial fibers in the adult rat cerebellum.

Authors:  Starlee Lively; Ian R Brown
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Authors:  Matt S Weaver; Gail Workman; Marina Cardo-Vila; Wadih Arap; Renata Pasqualini; E Helene Sage
Journal:  J Biol Chem       Date:  2009-12-15       Impact factor: 5.157

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7.  Differential expression patterns of occ1-related genes in adult monkey visual cortex.

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Journal:  Cereb Cortex       Date:  2008-12-10       Impact factor: 5.357

8.  The role of astrocyte-secreted matricellular proteins in central nervous system development and function.

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Journal:  J Cell Commun Signal       Date:  2009-11-11       Impact factor: 5.782

9.  Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury.

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Review 10.  Astrocyte-secreted matricellular proteins in CNS remodelling during development and disease.

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