| Literature DB >> 18335312 |
Abstract
SC1 is an extracellular matrix protein that belongs to the SPARC family of matricellular molecules. This anti-adhesive protein localizes to synapses in the adult rat brain and has been postulated to modulate synapse shape. In this study, increased levels of SC1 were detected from postnatal days 10-20, with a peak at postnatal day 15, a period of intense synaptogenesis. During this time, increased colocalization of SC1 with the synaptic marker synaptophysin was observed in synapse-rich regions of the cerebellum and the cerebral cortex. These findings indicate that the pattern of SC1 localization coincided with synaptogenesis during rat postnatal development.Entities:
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Year: 2008 PMID: 18335312 DOI: 10.1007/s11064-008-9606-z
Source DB: PubMed Journal: Neurochem Res ISSN: 0364-3190 Impact factor: 3.996