AIMS: To assess the relation between the atrial fibrillation (AF) subtype and thrombo-embolic events. METHODS AND RESULTS: The observational Euro Heart Survey on AF (2003-04) enrolled 1509 paroxysmal, 1109 persistent, and 1515 permanent AF patients, according to the 2001 American College of Cardiology, American Heart Association, and the European Society of Cardiology guidelines definitions. A 1 year follow-up was performed. Permanent AF patients had at baseline a worse stroke risk profile than paroxysmal and persistent AF patients. In paroxysmal AF, the risk for stroke, any thrombo-embolism, major bleeding and the combined endpoint of cardiovascular mortality, any thrombo-embolism, and major bleeding was comparable with persistent and permanent AF, in both univariable and multivariable analyses. Compared with AF patients without stroke, patients suffering from a stroke had a comparable frequency and duration of AF attacks, but tended to have a worse stroke risk profile at baseline. During 1 year following cardioversion, paroxysmal AF patients had a higher risk for stroke (P = 0.029) and any thrombo-embolism (P = 0.001) than persistent AF patients. CONCLUSION: In the Euro Heart Survey, paroxysmal AF had a comparable risk for thrombo-embolic events as persistent and permanent AF. This observation strengthens the guideline recommendation not to consider the clinical AF subtype when deciding on anticoagulation.
AIMS: To assess the relation between the atrial fibrillation (AF) subtype and thrombo-embolic events. METHODS AND RESULTS: The observational Euro Heart Survey on AF (2003-04) enrolled 1509 paroxysmal, 1109 persistent, and 1515 permanent AFpatients, according to the 2001 American College of Cardiology, American Heart Association, and the European Society of Cardiology guidelines definitions. A 1 year follow-up was performed. Permanent AFpatients had at baseline a worse stroke risk profile than paroxysmal and persistent AFpatients. In paroxysmal AF, the risk for stroke, any thrombo-embolism, major bleeding and the combined endpoint of cardiovascular mortality, any thrombo-embolism, and major bleeding was comparable with persistent and permanent AF, in both univariable and multivariable analyses. Compared with AFpatients without stroke, patients suffering from a stroke had a comparable frequency and duration of AF attacks, but tended to have a worse stroke risk profile at baseline. During 1 year following cardioversion, paroxysmal AFpatients had a higher risk for stroke (P = 0.029) and any thrombo-embolism (P = 0.001) than persistent AFpatients. CONCLUSION: In the Euro Heart Survey, paroxysmal AF had a comparable risk for thrombo-embolic events as persistent and permanent AF. This observation strengthens the guideline recommendation not to consider the clinical AF subtype when deciding on anticoagulation.
Authors: Christian Müller; Ulf Hengstmann; Michael Fuchs; Martin Kirchner; Frank Kleinjung; Harald Mathis; Stephan Martin; Ingo Bläse; Stefan Perings Journal: Digit Health Date: 2021-05-22
Authors: Karl Georg Haeusler; Juliane Herm; Claudia Kunze; Matthias Krüll; Lars Brechtel; Jürgen Lock; Marc Hohenhaus; Peter U Heuschmann; Jochen B Fiebach; Wilhelm Haverkamp; Matthias Endres; Gerhard Jan Jungehulsing Journal: BMC Cardiovasc Disord Date: 2012-08-31 Impact factor: 2.298
Authors: Karl Georg Haeusler; Andrea Gerth; Tobias Limbourg; Ulrich Tebbe; Michael Oeff; Karl Wegscheider; András Treszl; Ursula Ravens; Thomas Meinertz; Paulus Kirchhof; Günter Breithardt; Gerhard Steinbeck; Michael Nabauer Journal: BMC Neurol Date: 2015-08-05 Impact factor: 2.474