BACKGROUND: Cyto-histological diagnosis of pancreatic pathology in the management of suspected pancreatic malignancy is re-evaluated in the light of evolving trends in management and tissue sampling. METHODS: The literature on cyto-histological diagnosis of pancreatic pathology was reviewed over the period 1977-2003. RESULTS AND CONCLUSION: Endoluminal techniques of tissue sampling carry less risk of tumour seeding and are the sampling methods of choice for potentially resectable lesions if a tissue diagnosis will alter therapy. Endosonar-guided biopsy in expert hands appears to be the most reliable tissue sampling technique. Transcoelomic sampling methods should be reserved for those with un-resectable disease. All methods of cyto-histological diagnosis have high specificity but have a low negative predictive value. Therefore, potentially resectable lesions that are highly suspicious for malignancy should be explored even if pre-operative histology or cytology is negative.
BACKGROUND: Cyto-histological diagnosis of pancreatic pathology in the management of suspected pancreatic malignancy is re-evaluated in the light of evolving trends in management and tissue sampling. METHODS: The literature on cyto-histological diagnosis of pancreatic pathology was reviewed over the period 1977-2003. RESULTS AND CONCLUSION: Endoluminal techniques of tissue sampling carry less risk of tumour seeding and are the sampling methods of choice for potentially resectable lesions if a tissue diagnosis will alter therapy. Endosonar-guided biopsy in expert hands appears to be the most reliable tissue sampling technique. Transcoelomic sampling methods should be reserved for those with un-resectable disease. All methods of cyto-histological diagnosis have high specificity but have a low negative predictive value. Therefore, potentially resectable lesions that are highly suspicious for malignancy should be explored even if pre-operative histology or cytology is negative.
Authors: A Rumalla; T H Baron; O Leontovich; L J Burgart; R F Yacavone; T M Therneau; P C de Groen; T J Sebo Journal: Mayo Clin Proc Date: 2001-01 Impact factor: 7.616
Authors: Chiang J Tyng; Maria Fernanda A Almeida; Paula N V Barbosa; Almir G V Bitencourt; José Augusto A G Berg; Macello S Maciel; Felipe J F Coimbra; Luiz Henrique O Schiavon; Maria Dirlei Begnami; Marcos D Guimarães; Charles E Zurstrassen; Rubens Chojniak Journal: World J Gastroenterol Date: 2015-03-28 Impact factor: 5.742
Authors: Ryan K Schmocker; David J Vanness; Caprice C Greenberg; Jeff A Havlena; Noelle K LoConte; Jennifer M Weiss; Heather B Neuman; Glen Leverson; Maureen A Smith; Emily R Winslow Journal: HPB (Oxford) Date: 2017-02-23 Impact factor: 3.647
Authors: Andreas W Berger; Daniel Schwerdel; Anke Reinacher-Schick; Waldemar Uhl; Hana Algül; Helmut Friess; Klaus-Peter Janssen; Alexander König; Michael Ghadimi; Eike Gallmeier; Detlef K Bartsch; Michael Geissler; Ludger Staib; Andrea Tannapfel; Alexander Kleger; Alica Beutel; Lucas-Alexander Schulte; Marko Kornmann; Thomas J Ettrich; Thomas Seufferlein Journal: Theranostics Date: 2019-02-12 Impact factor: 11.556