Patrick F Sullivan1. 1. Department of Genetics, University of North Carolina at Chapel Hill, NC 27599-7264, USA. pfsulliv@med.unc.edu
Abstract
PURPOSE OF REVIEW: To describe the rationale for searching for genes for schizophrenia, prior efforts via candidate gene association and genomewide linkage studies, and to set the stage for the numerous genomewide association studies that will emerge by the end of 2008. RECENT FINDINGS: Genomewide association studies have identified dozens of new and previously unsuspected candidate genes for many biomedical disorders. At least seven new studies of approximately 20,000 cases plus controls are expected to be completed by the end of 2008. SUMMARY: Current results have few implications for clinical practice or research, and it is possible that this recommendation could be dramatically different in a year.
PURPOSE OF REVIEW: To describe the rationale for searching for genes for schizophrenia, prior efforts via candidate gene association and genomewide linkage studies, and to set the stage for the numerous genomewide association studies that will emerge by the end of 2008. RECENT FINDINGS: Genomewide association studies have identified dozens of new and previously unsuspected candidate genes for many biomedical disorders. At least seven new studies of approximately 20,000 cases plus controls are expected to be completed by the end of 2008. SUMMARY: Current results have few implications for clinical practice or research, and it is possible that this recommendation could be dramatically different in a year.
Authors: Mousumi Mutsuddi; Derek W Morris; Skye G Waggoner; Mark J Daly; Edward M Scolnick; Pamela Sklar Journal: Am J Hum Genet Date: 2006-10-03 Impact factor: 11.025
Authors: J K Millar; J C Wilson-Annan; S Anderson; S Christie; M S Taylor; C A Semple; R S Devon; D M St Clair; W J Muir; D H Blackwood; D J Porteous Journal: Hum Mol Genet Date: 2000-05-22 Impact factor: 6.150
Authors: P F Sullivan; D Lin; J-Y Tzeng; E van den Oord; D Perkins; T S Stroup; M Wagner; S Lee; F A Wright; F Zou; W Liu; A M Downing; J Lieberman; S L Close Journal: Mol Psychiatry Date: 2008-03-18 Impact factor: 15.992
Authors: Hreinn Stefansson; Engilbert Sigurdsson; Valgerdur Steinthorsdottir; Soley Bjornsdottir; Thordur Sigmundsson; Shyamali Ghosh; Jon Brynjolfsson; Steinunn Gunnarsdottir; Omar Ivarsson; Thomas T Chou; Omar Hjaltason; Birgitta Birgisdottir; Helgi Jonsson; Vala G Gudnadottir; Elsa Gudmundsdottir; Asgeir Bjornsson; Brynjolfur Ingvarsson; Andres Ingason; Sigmundur Sigfusson; Hronn Hardardottir; Richard P Harvey; Donna Lai; Mingdong Zhou; Daniela Brunner; Vincent Mutel; Acuna Gonzalo; Greg Lemke; Jesus Sainz; Gardar Johannesson; Thorkell Andresson; Daniel Gudbjartsson; Andrei Manolescu; Michael L Frigge; Mark E Gurney; Augustine Kong; Jeffrey R Gulcher; Hannes Petursson; Kari Stefansson Journal: Am J Hum Genet Date: 2002-07-23 Impact factor: 11.025
Authors: Richard E Straub; Yuxin Jiang; Charles J MacLean; Yunlong Ma; Bradley T Webb; Maxim V Myakishev; Carole Harris-Kerr; Brandon Wormley; Hannah Sadek; Bharat Kadambi; Anthony J Cesare; Avi Gibberman; Xu Wang; F Anthony O'Neill; Dermot Walsh; Kenneth S Kendler Journal: Am J Hum Genet Date: 2002-07-03 Impact factor: 11.025
Authors: Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy Journal: Science Date: 2007-04-12 Impact factor: 47.728
Authors: Cathryn M Lewis; Douglas F Levinson; Lesley H Wise; Lynn E DeLisi; Richard E Straub; Iiris Hovatta; Nigel M Williams; Sibylle G Schwab; Ann E Pulver; Stephen V Faraone; Linda M Brzustowicz; Charles A Kaufmann; David L Garver; Hugh M D Gurling; Eva Lindholm; Hilary Coon; Hans W Moises; William Byerley; Sarah H Shaw; Andrea Mesen; Robin Sherrington; F Anthony O'Neill; Dermot Walsh; Kenneth S Kendler; Jesper Ekelund; Tiina Paunio; Jouko Lönnqvist; Leena Peltonen; Michael C O'Donovan; Michael J Owen; Dieter B Wildenauer; Wolfgang Maier; Gerald Nestadt; Jean-Louis Blouin; Stylianos E Antonarakis; Bryan J Mowry; Jeremy M Silverman; Raymond R Crowe; C Robert Cloninger; Ming T Tsuang; Dolores Malaspina; Jill M Harkavy-Friedman; Dragan M Svrakic; Anne S Bassett; Jennifer Holcomb; Gursharan Kalsi; Andrew McQuillin; Jon Brynjolfson; Thordur Sigmundsson; Hannes Petursson; Elena Jazin; Tomas Zoëga; Tomas Helgason Journal: Am J Hum Genet Date: 2003-06-11 Impact factor: 11.025
Authors: Sylvie Devalle; Rafaela C Sartore; Bruna S Paulsen; Helena L Borges; Rodrigo A P Martins; Stevens K Rehen Journal: Front Cell Neurosci Date: 2012-09-05 Impact factor: 5.505
Authors: Joseph D Buxbaum; Nadia Bolshakova; Jessica M Brownfeld; Richard Jl Anney; Patrick Bender; Raphael Bernier; Edwin H Cook; Hilary Coon; Michael Cuccaro; Christine M Freitag; Joachim Hallmayer; Daniel Geschwind; Sabine M Klauck; John I Nurnberger; Guiomar Oliveira; Dalila Pinto; Fritz Poustka; Stephen W Scherer; Andy Shih; James S Sutcliffe; Peter Szatmari; Astrid M Vicente; Veronica Vieland; Louise Gallagher Journal: Mol Autism Date: 2014-05-20 Impact factor: 7.509