Literature DB >> 18331794

Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors.

Geraldine C Harriman1, Matthias Brewer, Robert Bennett, Cyrille Kuhn, Marc Bazin, Greg Larosa, Paul Skerker, Nancy Cochran, Debra Gallant, Deborah Baxter, Dominic Picarella, Bruce Jaffee, Jay R Luly, Michael J Briskin.   

Abstract

A novel series of barbituric acid derivatives were identified as selective inhibitors of alpha4beta7 MAdCAM (mucosal addressin cell adhesion molecule-1) interactions via a high throughput screening exercise. These inhibitors were optimized to submicromolar potencies in whole cell adhesion assays, retaining their selectivity over alpha4beta1 VCAM.

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Year:  2007        PMID： 18331794     DOI： 10.1016/j.bmcl.2007.07.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Boc-protected 1-(3-oxocycloalkyl)ureas via a one-step Curtius rearrangement: mechanism and scope.

Authors:  Xianyu Sun; Rachita Rai; Jeffrey R Deschamps; Alexander D Mackerell; Alan I Faden; Fengtian Xue
Journal:  Tetrahedron Lett       Date:  2014-01-22       Impact factor: 2.415

2.  Anticancer potential of aminomethylidene-diazinanes I. Synthesis of arylaminomethylidene of diazinetriones and its cytotoxic effects tested in glioblastoma cells.

Authors:  Nichole A Pianovich; Mathew Dean; Adam Lassak; Krzysztof Reiss; Branko S Jursic
Journal:  Bioorg Med Chem       Date:  2017-08-12       Impact factor: 3.641

3.  Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

Authors:  Syed A Rizvi; Erin M Neidt; Jiayue Cui; Zach Feiger; Colleen T Skau; Margaret L Gardel; Sergey A Kozmin; David R Kovar
Journal:  Chem Biol       Date:  2009-11-25

4.  Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector.

Authors:  Bijo Mathew; Jerad Suresh; Socklingam Anbazhagan
Journal:  J Pharm Bioallied Sci       Date:  2013-01

5.  Fe(III)-montmorillonite catalysed one pot synthesis of 5-substituted dihydropyrimidine derivatives as potent antimicrobial agents.

Authors:  Vinoda B M; Yadav D Bodke; Sandeep Telkar; Aruna Sindhe M; Talavara Venkatesh
Journal:  J Taibah Univ Med Sci       Date:  2016-08-18
  5 in total

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