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Literature DB >> 18331708

Yorkie and Scalloped: partners in growth activation.

Abstract

The Hippo (Hpo) signaling pathway limits organ growth in organisms from Drosophila to mammals by suppressing the activity of the transcriptional coactivator Yorkie (Yki)/YAP. The TEAD/TEF factor Scalloped (Sd) has been identified as the first known transcription factor to partner with Yki as a downstream target of Hpo signaling.

Entities: Gene Species

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Year: 2008 PMID： 18331708 DOI： 10.1016/j.devcel.2008.02.010

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

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Cited

8 in total

1. Expression and function of scalloped during Drosophila development.

Authors: Kirsten A Guss; Michael Benson; Nicholas Gubitosi; Karrie Brondell; Kendal Broadie; James B Skeath
Journal: Dev Dyn Date: 2013-06-03 Impact factor: 3.780

2. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation.

Authors: Siew Wee Chan; Chun Jye Lim; Li Shen Loo; Yaan Fun Chong; Caixia Huang; Wanjin Hong
Journal: J Biol Chem Date: 2009-03-26 Impact factor: 5.157

3. Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.

Authors: Richelle Sopko; Elizabeth Silva; Lesley Clayton; Laura Gardano; Miriam Barrios-Rodiles; Jeff Wrana; Xaralabos Varelas; Natalia I Arbouzova; Sanjeev Shaw; Sakura Saburi; Hitoshi Matakatsu; Seth Blair; Helen McNeill
Journal: Curr Biol Date: 2009-06-18 Impact factor: 10.834

Yorkie and Scalloped: partners in growth activation.

1. Expression and function of scalloped during Drosophila development.

2. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation.

3. Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.

4. AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma.

5. WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ.

6. The Hippo pathway as a target of the Drosophila DRE/DREF transcriptional regulatory pathway.

7. Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

8. TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer.