OBJECTIVE: As residents of sub-Saharan Africa are at high risk for HIV and cholera, it is biologically plausible that immune suppression caused by HIV infection predisposes to cholera. Our aim was to assess the potential association between both diseases. METHODS: We conducted a case-control study in Beira, Mozambique, a high-risk area for HIV and cholera. Between 1 January 2005 and 30 June 2006, experienced counsellors invited 132 suspected cholera cases and 528 age- and sex-matched controls to an HIV counselling and testing centre. RESULTS: Forty (30%) of the invited cases and 127 (24%) of the invited controls came for HIV testing. No significant differences in demographic and socio-economic baseline characteristics were detected between participants and non-participants. Twenty five of 167 (15%) individuals who underwent testing were found HIV-positive. The probability of a positive HIV-test was highest in participants between 40 and 49 years; 6 of 14 (43%) tested HIV-positive. Nine of 40 (23%) cholera cases were found to be HIV-infected compared with 16 of 127 (13%) controls (adjusted odds ratio 2.6; 95% CI 0.9-7.5; P = 0.08). DISCUSSION: The findings suggest that in a cholera-endemic area, HIV infection is associated with an increased risk for cholera. More research in HIV endemic settings is needed to confirm the findings and to explore the effect of HIV-related immunosuppression on the transmission of cholera.
OBJECTIVE: As residents of sub-Saharan Africa are at high risk for HIV and cholera, it is biologically plausible that immune suppression caused by HIV infection predisposes to cholera. Our aim was to assess the potential association between both diseases. METHODS: We conducted a case-control study in Beira, Mozambique, a high-risk area for HIV and cholera. Between 1 January 2005 and 30 June 2006, experienced counsellors invited 132 suspected cholera cases and 528 age- and sex-matched controls to an HIV counselling and testing centre. RESULTS: Forty (30%) of the invited cases and 127 (24%) of the invited controls came for HIV testing. No significant differences in demographic and socio-economic baseline characteristics were detected between participants and non-participants. Twenty five of 167 (15%) individuals who underwent testing were found HIV-positive. The probability of a positive HIV-test was highest in participants between 40 and 49 years; 6 of 14 (43%) tested HIV-positive. Nine of 40 (23%) cholera cases were found to be HIV-infected compared with 16 of 127 (13%) controls (adjusted odds ratio 2.6; 95% CI 0.9-7.5; P = 0.08). DISCUSSION: The findings suggest that in a cholera-endemic area, HIV infection is associated with an increased risk for cholera. More research in HIV endemic settings is needed to confirm the findings and to explore the effect of HIV-related immunosuppression on the transmission of cholera.
Authors: Louise C Ivers; Richelle C Charles; Isabelle J Hilaire; Leslie M Mayo-Smith; Jessica E Teng; J Gregory Jerome; Jenna Rychert; Regina C LaRocque; Peng Xu; Pavol Kovácˇ; Edward T Ryan; Firdausi Qadri; Charles P Almazor; Molly F Franke; Jason B Harris Journal: J Infect Dis Date: 2015-02-26 Impact factor: 5.226
Authors: Karine Sévère; Stravinsky B Anglade; Claudin Bertil; Aynsley Duncan; Patrice Joseph; Alexandra Deroncenay; Marie M Mabou; Oksana Ocheretina; Lindsey Reif; Grace Seo; Jean W Pape; Daniel W Fitzgerald Journal: Am J Trop Med Hyg Date: 2016-08-22 Impact factor: 2.345
Authors: Aaron Richterman; Hoi Ching Cheung; Mark K Meiselbach; Gregory Jerome; Ralph Ternier; Louise C Ivers Journal: Open Forum Infect Dis Date: 2018-05-31 Impact factor: 3.835
Authors: Claude-Lyne Valcin; Karine Severe; Claudia T Riche; Benedict S Anglade; Colette Guiteau Moise; Michael Woodworth; Macarthur Charles; Zhongze Li; Patrice Joseph; Jean W Pape; Peter F Wright Journal: Am J Trop Med Hyg Date: 2013-10 Impact factor: 2.345