Azizi Arash1, Lawaf Shirin. 1. Department of Oral Medicine, Faculty of Dentistry, Ahwaz University of Medical Sciences, Ahwaz, Iran. drarashazizi@yahoo.com
Abstract
STATEMENT OF PROBLEM: Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial disease that primarily affects the mucous membranes of patients over the age of 50 years, resulting in mucosal ulceration and subsequent scarring. PURPOSE: The purpose of this study was to investigate the efficacy of dapsone in combination with topical corticosteroids to treat the oral lesions of MMP. MATERIALS AND METHODS: Twenty-two patients who had been diagnosed with MMP were selected. The oral features were graded according to severity of disease from 1 to 3. Each patient was assigned to one of four groups according to his or her response to therapy. RESULTS: Five patients with mild to moderate disease were treated with topical corticosteroids alone for the duration of the study; 15 patients with moderate to severe disease were treated by topical corticosteroid with dapsone therapy. All of 15 patients had significant benefits. CONCLUSIONS: The use of dapsone in combination with topical corticosteroids is one of the most useful methods for the treatment of MMP.
STATEMENT OF PROBLEM: Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial disease that primarily affects the mucous membranes of patients over the age of 50 years, resulting in mucosal ulceration and subsequent scarring. PURPOSE: The purpose of this study was to investigate the efficacy of dapsone in combination with topical corticosteroids to treat the oral lesions of MMP. MATERIALS AND METHODS: Twenty-two patients who had been diagnosed with MMP were selected. The oral features were graded according to severity of disease from 1 to 3. Each patient was assigned to one of four groups according to his or her response to therapy. RESULTS: Five patients with mild to moderate disease were treated with topical corticosteroids alone for the duration of the study; 15 patients with moderate to severe disease were treated by topical corticosteroid with dapsone therapy. All of 15 patients had significant benefits. CONCLUSIONS: The use of dapsone in combination with topical corticosteroids is one of the most useful methods for the treatment of MMP.