Literature DB >> 18331231

RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease.

Xi Chen1, Douglas G Walker, Ann Marie Schmidt, Ottavio Arancio, Lih-Fen Lue, Shi Du Yan.   

Abstract

This review focuses on the current findings regarding interaction between amyloid beta peptide (Abeta) and receptor for advanced glycation endproducts (RAGE) and its roles in the pathogenesis of Alzheimer's disease (AD). As a ubiquitously expressed cell surface receptor, RAGE mediates the effects of Abeta on microglia, blood-brain barrier (BBB) and neurons through activating different signaling pathways. Data from autopsy brain tissues, in vitro cell cultures and transgenic mouse models suggest that Abeta-RAGE interaction exaggerates neuronal stress, accumulation of Abeta, impaired learning memory, and neuroinflammation. Blockade of RAGE protects against Abeta-mediated cellular perturbation. These findings may have an important therapeutic implication for neurodegenerative disorders relevant to AD.

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Year:  2007        PMID： 18331231     DOI： 10.2174/156652407783220741

Source DB:  PubMed          Journal:  Curr Mol Med        ISSN： 1566-5240            Impact factor:   2.222


  59 in total

1.  Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex.

Authors:  Nicola Origlia; Camilla Bonadonna; Alfredo Rosellini; Elena Leznik; Ottavio Arancio; Shirley Shidu Yan; Luciano Domenici
Journal:  J Neurosci       Date:  2010-08-25       Impact factor: 6.167

2.  The interaction of amyloid β and the receptor for advanced glycation endproducts induces matrix metalloproteinase-2 expression in brain endothelial cells.

Authors:  Huan Du; Pengtao Li; Jun Wang; Xuemei Qing; Weihong Li
Journal:  Cell Mol Neurobiol       Date:  2011-08-12       Impact factor: 5.046

3.  Perforin Promotes Amyloid Beta Internalisation in Neurons.

Authors:  Erica Lana; Mahbod Khanbolouki; Charline Degavre; Eva-Britt Samuelsson; Elisabet Åkesson; Bengt Winblad; Evren Alici; Christina Unger Lithner; Homira Behbahani
Journal:  Mol Neurobiol       Date:  2016-01-16       Impact factor: 5.590

Review 4.  Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.

Authors:  Tae-In Kam; Youngdae Gwon; Yong-Keun Jung
Journal:  Cell Mol Life Sci       Date:  2014-08-24       Impact factor: 9.261

5.  β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer's Disease.

Authors:  Cong Yang; Xiaoguang Li; Yousheng Mo; Sijun Liu; Luguang Zhao; Xiaohui Ma; Zhigang Fang; Junli Chen; Yunbo Chen; Xuhua Yu; Shuhuan Fang; Yongbin Zhang; Shaoxiang Xian; Qi Wang
Journal:  Cell Mol Neurobiol       Date:  2015-08-14       Impact factor: 5.046

Review 6.  Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature.

Authors:  Tony Wyss-Coray; Joseph Rogers
Journal:  Cold Spring Harb Perspect Med       Date:  2012-01       Impact factor: 6.915

7.  RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

Authors:  Fang Fang; Lih-Fen Lue; Shiqiang Yan; Hongwei Xu; John S Luddy; Doris Chen; Douglas G Walker; David M Stern; Shifang Yan; Ann Marie Schmidt; John X Chen; Shirley ShiDu Yan
Journal:  FASEB J       Date:  2009-11-11       Impact factor: 5.191

8.  Association between the RAGE G82S polymorphism and Alzheimer's disease.

Authors:  Keshen Li; Dawei Dai; Bin Zhao; Lifen Yao; Songpo Yao; Binyou Wang; Ze Yang
Journal:  J Neural Transm (Vienna)       Date:  2009-11-10       Impact factor: 3.575

9.  RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.

Authors:  Kazuhiro Takuma; Fang Fang; Wensheng Zhang; Shiqiang Yan; Emiko Fukuzaki; Heng Du; Alexander Sosunov; Guy McKhann; Yoko Funatsu; Noritaka Nakamichi; Taku Nagai; Hiroyuki Mizoguchi; Daisuke Ibi; Osamu Hori; Satoshi Ogawa; David M Stern; Kiyofumi Yamada; Shirley Shidu Yan
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-09       Impact factor: 11.205

10.  Involvement of α7nAChR in the Protective Effects of Genistein Against β-Amyloid-Induced Oxidative Stress in Neurons via a PI3K/Akt/Nrf2 Pathway-Related Mechanism.

Authors:  Jianbin Guo; Guoqing Yang; Yuqing He; Huiming Xu; Hong Fan; Jing An; Lingling Zhang; Rui Zhang; Guihua Cao; Dingjun Hao; Hao Yang
Journal:  Cell Mol Neurobiol       Date:  2020-11-19       Impact factor: 5.046
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