AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD +/- 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity.
AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD +/- 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS:Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity.
Authors: Hyun Kyung Kim; Kyoung Rhan Lee; Jeon Ho Yang; Sung Jae Yoo; Sang Won Lee; Hyun-Jung Jang; Sang Jae Park; Young-Soo Moon; Joong-Won Park; Chang-Min Kim Journal: Thromb Res Date: 2003-01-25 Impact factor: 3.944
Authors: V Toschi; G M Rocchini; A Motta; G F Fiorini; C Cimminiello; F Violi; C Castelli; D Sironi; A Gibelli Journal: Biomed Pharmacother Date: 1993 Impact factor: 6.529
Authors: Johannes Thaler; Ton Lisman; Peter Quehenberger; Lena Hell; Philipp Schwabl; Bernhard Scheiner; Theresa Bucsics; Rienk Nieuwland; Cihan Ay; Michael Trauner; Ingrid Pabinger; Thomas Reiberger; Mattias Mandorfer Journal: Thromb Haemost Date: 2021-07-04 Impact factor: 6.681
Authors: Alvaro H Borges; Jemma L O'Connor; Andrew N Phillips; Jason V Baker; Michael J Vjecha; Marcelo H Losso; Hartwig Klinker; Gustavo Lopardo; Ian Williams; Jens D Lundgren Journal: PLoS One Date: 2014-03-13 Impact factor: 3.240