PURPOSE: To identify results and prognostic factors on long-term survival and local control following treatment of localized Ewing's sarcoma. PATIENTS AND METHODS: Between 1979 and 2004, a total of 60 children and young adults with Ewing's sarcoma were treated. Patients with distant metastases at presentation (n = 6) and recurrent cases (n = 2) were excluded from this analysis. Patients were exclusively treated within ongoing national and international protocols CESS-81, CESS-86, EICESS-92, EURO-EWING-99. All patients received local irradiation with a total dose of 45-60 Gy; in addition, 41 (79%) of the patients had local surgical procedures, 27 (52%) of them with clear margins. RESULTS: Overall survival rates at 5 and 10 years were 56% and 45%, respectively. Patients <or= 14 years at diagnosis had overall survival rates of 66% and 61% at 5 and 10 years compared to older patients with corresponding survival rates of 47% and 31%, respectively (p = 0.05). Patients with tumors of lower volume (<or= 100 ml) had significantly better survival rates at 5 and 10 years: 82% and 60% versus 42% und 39% (p = 0.03). Seven of 52 (14%) patients experienced local failure; no significant impact was noted for any of the following factors: treatment protocol, radiation dose, surgery. CONCLUSION: Radiotherapy with and without surgery of Ewing's sarcoma is a highly effective local treatment option. It seems preferable to mutilating surgery.
PURPOSE: To identify results and prognostic factors on long-term survival and local control following treatment of localized Ewing's sarcoma. PATIENTS AND METHODS: Between 1979 and 2004, a total of 60 children and young adults with Ewing's sarcoma were treated. Patients with distant metastases at presentation (n = 6) and recurrent cases (n = 2) were excluded from this analysis. Patients were exclusively treated within ongoing national and international protocols CESS-81, CESS-86, EICESS-92, EURO-EWING-99. All patients received local irradiation with a total dose of 45-60 Gy; in addition, 41 (79%) of the patients had local surgical procedures, 27 (52%) of them with clear margins. RESULTS: Overall survival rates at 5 and 10 years were 56% and 45%, respectively. Patients <or= 14 years at diagnosis had overall survival rates of 66% and 61% at 5 and 10 years compared to older patients with corresponding survival rates of 47% and 31%, respectively (p = 0.05). Patients with tumors of lower volume (<or= 100 ml) had significantly better survival rates at 5 and 10 years: 82% and 60% versus 42% und 39% (p = 0.03). Seven of 52 (14%) patients experienced local failure; no significant impact was noted for any of the following factors: treatment protocol, radiation dose, surgery. CONCLUSION: Radiotherapy with and without surgery of Ewing's sarcoma is a highly effective local treatment option. It seems preferable to mutilating surgery.
Authors: Jose Luis Lopez; Patricia Cabrera; Rafael Ordoñez; Catalina Marquez; Gema Lucia Ramirez; Juan Manuel Praena-Fernandez; Maria Jose Ortiz Journal: Rep Pract Oncol Radiother Date: 2011-03-12
Authors: Maximilian Rudert; Cornelia Winkler; Boris Michael Holzapfel; Hans Rechl; Peter Kneschaurek; Reiner Gradinger; Michael Molls; Barbara Röper Journal: Strahlenther Onkol Date: 2010-03-26 Impact factor: 3.621
Authors: K Müller; B Diez; A Muggeri; T Pietsch; C Friedrich; S Rutkowski; K von Hoff; A O von Bueren; I Zwiener; F Bruns Journal: Strahlenther Onkol Date: 2013-03-23 Impact factor: 3.621