Literature DB >> 1833033

NMDA receptor antagonists block the induction of long-term depression in the hippocampal dentate gyrus of the anesthetized rat.

N L Desmond1, C M Colbert, D X Zhang, W B Levy.   

Abstract

The present study tested the effect of two non-competitive NMDA receptor antagonists, ketamine and phencyclidine, on the induction of long-term depression (LTD) in the dentate gyrus of urethane-anesthetized rats. Both drugs blocked the induction of LTD as well as long-term potentiation (LTP). NMDA receptor activation thus seems to be required for the induction of both LTD and LTP in the dentate gyrus. High-intensity conditioning stimulation did not overcome the phencyclidine block of LTD. Strong, but brief, postsynaptic depolarization is apparently not the only event needed to trigger LTD.

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Year:  1991        PMID： 1833033     DOI： 10.1016/0006-8993(91)90664-h

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Reciprocal inhibition of the AMPA and NMDA components of excitatory postsynaptic potentials in field CA1 of the rat hippocampus in vitro.

Authors:  A V Bazhenov; A M Kleshchevnikov
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2.  Orphanin FQ suppresses NMDA receptor-dependent long-term depression and depotentiation in hippocampal dentate gyrus.

Authors:  W Z Wei; C W Xie
Journal:  Learn Mem       Date:  1999 Sep-Oct       Impact factor: 2.460

3.  Antidepressants that inhibit both serotonin and norepinephrine reuptake impair long-term potentiation in hippocampus.

Authors:  Jennifer D Cooke; Hannah M Cavender; Hope K Lima; Lawrence M Grover
Journal:  Psychopharmacology (Berl)       Date:  2014-04-30       Impact factor: 4.530

4.  N-methyl-D-aspartate receptor blockade reduces plasticity-related tau expression and phosphorylation of tau at Ser416 residue but not Thr231 residue.

Authors:  Burak Tan; Ezgi Aslan-Gülpınar; Nurcan Dursun; Cem Süer
Journal:  Exp Brain Res       Date:  2021-03-25       Impact factor: 1.972

5.  Discovering Associative Long-term Synaptic Modification and Timing Dependence of Plasticity - a Very Brief and Personal History.

Authors:  William B Levy
Journal:  Front Synaptic Neurosci       Date:  2010-12-02

6.  Neurobiology of the integrative activity of the brain: some properties of long-term posttetanic heterosynaptic depression in the motor cortex of the cat.

Authors:  I G Sil'kis; S Sh Rapoport; N V Veber; A M Gushchin
Journal:  Neurosci Behav Physiol       Date:  1994 Nov-Dec

Review 7.  Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory.

Authors:  Sabyasachi Maity; Raman Abbaspour; David Nahabedian; Steven A Connor
Journal:  Int J Mol Sci       Date:  2022-08-31       Impact factor: 6.208
  7 in total

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