Literature DB >> 18329885

Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.

Fang Liu1, Xiao-Qiong Luo, Bao-An Song, Pinaki S Bhadury, Song Yang, Lin-Hong Jin, Wei Xue, De-Yu Hu.   

Abstract

Selective oxidation of sulfides 7 or 8 to sulfoxides 9 or 10 is achieved by mCPBA. The structures of the compounds 9 or 10 are confirmed by elemental analysis, IR, and (1)H NMR. The bioassay results showed that title compound 10a possess high antifungal activities with EC(50) values ranging from 19.91 to 63.97 microg/mL. The mechanism of action of 10a against Sclerotinia sclerotiorum was studied. After treating with compound 10a at 100 microg/mL for 12 h, the mycelial reducing sugar, D-GlcNAc, soluble protein and pyruvate content, chitinase activity showed declining tendency.

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Year:  2008        PMID： 18329885     DOI： 10.1016/j.bmc.2008.02.006

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  14 in total

1.  Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles.

Authors:  Stesphanie L Breunig; Margaret E Olson; Daniel A Harki
Journal:  Tetrahedron Lett       Date:  2016-07-29       Impact factor: 2.415

2.  Synthesis and Antimicrobial Activity Screening of Piperazines Bearing N,N'-Bis(1,3,4-thiadiazole) Moiety as Probable Enoyl-ACP Reductase Inhibitors.

Authors:  Alaa Z Omar; Najla A Alshaye; Tawfik M Mosa; Samir K El-Sadany; Ezzat A Hamed; Mohamed A El-Atawy
Journal:  Molecules       Date:  2022-06-09       Impact factor: 4.927

3.  Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones.

Authors:  Navin B Patel; Jaymin C Patel
Journal:  Sci Pharm       Date:  2010-04-26

4.  Inorganic base-catalyzed formation of antivirally active N-substituted benzamides from α-amido sulfones and N-nucleophile.

Authors:  Yi Jin; Baoan Song; Deyu Hu; Xiangyang Li; Pinaki S Bhadury; Zhenchao Wang; Song Yang
Journal:  Chem Cent J       Date:  2011-05-05       Impact factor: 4.215

5.  2-Chloro-5-({[5-(4-meth-oxy-phen-yl)-1,3,4-oxadiazol-2-yl]-sulfanyl}-meth-yl)pyridine.

Authors:  Hao Ji; Xu-Dong Xu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-11-30

6.  Synthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychotics.

Authors:  Yin Chen; Xiangqing Xu; Xin Liu; Minquan Yu; Bi-Feng Liu; Guisen Zhang
Journal:  PLoS One       Date:  2012-04-30       Impact factor: 3.240

7.  Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold.

Authors:  Xinmin Zhong; Xiaobin Wang; Lijuan Chen; Xianghui Ruan; Qin Li; Juping Zhang; Zhuo Chen; Wei Xue
Journal:  Chem Cent J       Date:  2017-10-17       Impact factor: 4.215

8.  Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives.

Authors:  Anis Ahamed; Ibrahim A Arif; Mohammed Mateen; Radhakrishnan Surendra Kumar; Akbar Idhayadhulla
Journal:  Saudi J Biol Sci       Date:  2018-03-06       Impact factor: 4.219

9.  Synthesis, structure optimization and antifungal screening of novel tetrazole ring bearing acyl-hydrazones.

Authors:  Maqsood Ahmad Malik; Shaeel Ahmed Al-Thabaiti; Manzoor A Malik
Journal:  Int J Mol Sci       Date:  2012-08-30       Impact factor: 6.208

10.  Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole.

Authors:  Jian Wu; Shenghong Kang; Lijun Luo; Qingcai Shi; Juan Ma; Juan Yin; Baoan Song; Deyu Hu; Song Yang
Journal:  Chem Cent J       Date:  2013-04-05       Impact factor: 4.215
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