Literature DB >> 18329534

Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.

Nicholas A Flavahan1.   

Abstract

Because of the role of the RhoA/Rho kinase (ROCK) pathway in regulating numerous pathologic processes including vasoconstriction, vascular remodeling, and fibrosis, ROCK inhibitors may be especially beneficial in treating Raynaud's phenomenon and scleroderma.

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Year:  2008        PMID： 18329534      PMCID： PMC2336896          DOI： 10.1016/j.rdc.2007.12.005

Source DB:  PubMed          Journal:  Rheum Dis Clin North Am        ISSN： 0889-857X            Impact factor:   2.670


  40 in total

1.  Silent alpha(2C)-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries.

Authors:  M A Chotani; S Flavahan; S Mitra; D Daunt; N A Flavahan
Journal:  Am J Physiol Heart Circ Physiol       Date:  2000-04       Impact factor: 4.733

2.  Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2.

Authors:  M G Eason; S B Liggett
Journal:  J Biol Chem       Date:  1992-12-15       Impact factor: 5.157

3.  Subtype-specific intracellular trafficking of alpha2-adrenergic receptors.

Authors:  D A Daunt; C Hurt; L Hein; J Kallio; F Feng; B K Kobilka
Journal:  Mol Pharmacol       Date:  1997-05       Impact factor: 4.436

4.  Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.

Authors:  L Hein; J D Altman; B K Kobilka
Journal:  Nature       Date:  1999-11-11       Impact factor: 49.962

5.  Effect of cooling on alpha-1 and alpha-2 adrenergic responses in canine saphenous and femoral veins.

Authors:  N A Flavahan; P M Vanhoutte
Journal:  J Pharmacol Exp Ther       Date:  1986-07       Impact factor: 4.030

6.  Alpha 2-adrenoceptor inhibition in patients with vibration white fingers.

Authors:  L E Lindblad; L Ekenvall
Journal:  Kurume Med J       Date:  1990

7.  G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes.

Authors:  E A Jewell-Motz; S B Liggett
Journal:  J Biol Chem       Date:  1996-07-26       Impact factor: 5.157

8.  Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.

Authors:  M Honda; M Suzuki; K Nakayama; T Ishikawa
Journal:  Br J Pharmacol       Date:  2007-07-09       Impact factor: 8.739

9.  Blockade of vasospastic attacks by alpha 2-adrenergic but not alpha 1-adrenergic antagonists in idiopathic Raynaud's disease.

Authors:  R R Freedman; R P Baer; M D Mayes
Journal:  Circulation       Date:  1995-09-15       Impact factor: 29.690

10.  Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries.

Authors:  A H Eid; K Maiti; S Mitra; M A Chotani; S Flavahan; S R Bailey; C S Thompson-Torgerson; N A Flavahan
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-07-20       Impact factor: 4.733
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  11 in total

Review 1.  The pathogenesis, diagnosis and treatment of Raynaud phenomenon.

Authors:  Ariane L Herrick
Journal:  Nat Rev Rheumatol       Date:  2012-07-10       Impact factor: 20.543

Review 2.  Local thermal control of the human cutaneous circulation.

Authors:  John M Johnson; Dean L Kellogg
Journal:  J Appl Physiol (1985)       Date:  2010-06-03

3.  Molecular determinants of the human α2C-adrenergic receptor temperature-sensitive intracellular traffic.

Authors:  Catalin M Filipeanu; Ashok K Pullikuth; Jessie J Guidry
Journal:  Mol Pharmacol       Date:  2015-02-13       Impact factor: 4.436

4.  Endothelial Dysfunction and Nailfold Videocapillaroscopy Pattern as Predictors of Digital Ulcers in Systemic Sclerosis: a Cohort Study and Review of the Literature.

Authors:  Ivone Silva; Andreia Teixeira; José Oliveira; Isabel Almeida; Rui Almeida; Artur Águas; Carlos Vasconcelos
Journal:  Clin Rev Allergy Immunol       Date:  2015-10       Impact factor: 8.667

5.  Postjunctional α2C-adrenoceptors mediate vasoconstriction in rat tail artery: influence of precontraction and temperature on vasoreactivity.

Authors:  Florian Jantschak; Alexander M Popp; Raik A Hofmann; Carlos M Villalón; David Centurión; Heinz H Pertz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-09-24       Impact factor: 3.000

6.  Modulation of α(2C) adrenergic receptor temperature-sensitive trafficking by HSP90.

Authors:  Catalin M Filipeanu; René de Vries; A H Jan Danser; Daniel R Kapusta
Journal:  Biochim Biophys Acta       Date:  2010-12-09

7.  Raynaud's phenomenon and digital ischemia: a practical approach to risk stratification, diagnosis and management.

Authors:  Zsuzsanna H McMahan; Fredrick M Wigley
Journal:  Int J Clin Rheumtol       Date:  2010

Review 8.  Vascular disease in scleroderma.

Authors:  Fredrick M Wigley
Journal:  Clin Rev Allergy Immunol       Date:  2009-06       Impact factor: 8.667

9.  Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis.

Authors:  Amiq Gazdhar; Dirk Lebrecht; Michael Roth; Michael Tamm; Nils Venhoff; Chingching Foocharoen; Thomas Geiser; Ulrich A Walker
Journal:  Sci Rep       Date:  2014-06-18       Impact factor: 4.379

10.  Aging and the control of human skin blood flow.

Authors:  Lacy A Holowatz; Caitlin Thompson-Torgerson; W Larry Kenney
Journal:  Front Biosci (Landmark Ed)       Date:  2010-01-01
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