Literature DB >> 18329388

Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts.

Florence Debacq-Chainiaux1, Thierry Pascal, Emmanuelle Boilan, Coralie Bastin, Emilie Bauwens, Olivier Toussaint.   

Abstract

Repeated exposures to sublethal concentrations of tert-butylhydroperoxide and ethanol trigger premature senescence of WI-38 human diploid fibroblasts. We found 16 replicative senescence-related genes with similar alterations in expression level in replicative senescence and two models of stress-induced premature senescence. Among these genes was IGFBP-3. Using a siRNA approach, we showed that IGFBP-3 regulates the appearance of several biomarkers of senescence after repeated exposures of WI-38 fibroblasts to tert-butylhydroperoxide and ethanol.

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Year:  2008        PMID： 18329388     DOI： 10.1016/j.freeradbiomed.2008.02.001

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  24 in total

1.  Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line.

Authors:  Chen-Min Jiang; Xin Liu; Chun-Xue Li; Hao-Cheng Qian; Di Chen; Chao-Qiang Lai; Li-Rong Shen
Journal:  J Zhejiang Univ Sci B       Date:  2018 Dec.       Impact factor: 3.066

2.  A novel role for the condensin II complex in cellular senescence.

Authors:  Yuhki Yokoyama; Hengrui Zhu; Rugang Zhang; Ken-ichi Noma
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

3.  Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions.

Authors:  Liang Liang; Rivka C Stone; Olivera Stojadinovic; Horacio Ramirez; Irena Pastar; Anna G Maione; Avi Smith; Vanessa Yanez; Aristides Veves; Robert S Kirsner; Jonathan A Garlick; Marjana Tomic-Canic
Journal:  Wound Repair Regen       Date:  2016-10-04       Impact factor: 3.617

4.  Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch.

Authors:  Kotaro Fujimaki; Ruoyan Li; Hengyu Chen; Kimiko Della Croce; Hao Helen Zhang; Jianhua Xing; Fan Bai; Guang Yao
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-21       Impact factor: 11.205

5.  Accelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cells.

Authors:  Manali Phadke; Natalia Krynetskaia; Anurag Mishra; Evgeny Krynetskiy
Journal:  Biochem Biophys Res Commun       Date:  2011-07-02       Impact factor: 3.575

6.  IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment.

Authors:  Mitsuteru Natsuizaka; Hideaki Kinugasa; Shingo Kagawa; Kelly A Whelan; Seiji Naganuma; Harry Subramanian; Sanders Chang; Kei J Nakagawa; Naryan L Rustgi; Yoshiaki Kita; Shoji Natsugoe; Devraj Basu; Phyllis A Gimotty; Andres J Klein-Szanto; J Alan Diehl; Hiroshi Nakagawa
Journal:  Am J Cancer Res       Date:  2014-01-15       Impact factor: 6.166

7.  Copper ability to induce premature senescence in human fibroblasts.

Authors:  Liliana Matos; Alexandra Gouveia; Henrique Almeida
Journal:  Age (Dordr)       Date:  2011-06-22

8.  Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.

Authors:  Florence Debacq-Chainiaux; Jorge D Erusalimsky; Judith Campisi; Olivier Toussaint
Journal:  Nat Protoc       Date:  2009       Impact factor: 13.491

Review 9.  Chronic Kidney Disease: A Vicarious Relation to Premature Cell Senescence.

Authors:  Michael S Goligorsky
Journal:  Am J Pathol       Date:  2020-03-16       Impact factor: 4.307

10.  Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy.

Authors:  Mario Matthaei; Huan Meng; Alan K Meeker; Charles G Eberhart; Albert S Jun
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-09-28       Impact factor: 4.799
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