| Literature DB >> 18329267 |
Yun Feng Xie1, Ila Sircar, Kirk Lake, Mallareddy Komandla, Kathleen Ligsay, Jian Li, Kui Xu, Jason Parise, Lisa Schneider, Dingqiu Huang, Juping Liu, Naoki Sakurai, Miguel Barbosa, Rick Jack.
Abstract
A hit-to-lead optimization process was carried out on the high throughput screening hit compound 1 resulting in the identification of several potent and selective CCR1 receptor antagonists. Compound 37 shows the best overall profile with IC(50) values of <100 nM in binding and functional assays.Entities:
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Year: 2007 PMID： 18329267 DOI： 10.1016/j.bmcl.2007.09.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823