| Literature DB >> 18328762 |
Udo Lorenz1, Christian Hüttinger, Tina Schäfer, Wilma Ziebuhr, Arnulf Thiede, Jörg Hacker, Susanne Engelmann, Michael Hecker, Knut Ohlsen.
Abstract
The impact of the alternative sigma factor sigma B (SigB) on pathogenesis of Staphylococcus aureus is not conclusively clarified. In this study, a central venous catheter (CVC) related model of multiorgan infection was used to investigate the role of SigB for the pathogenesis of S. aureus infections and biofilm formation in vivo. Analysis of two SigB-positive wild-type strains and their isogenic mutants revealed uniformly that the wild-type was significantly more virulent than the SigB-deficient mutant. The observed difference in virulence was apparently not linked to the capability of the strains to form biofilms in vivo since wild-type and mutant strains were able to produce biofilm layers inside of the catheter. The data strongly indicate that the alternative sigma factor SigB plays a role in CVC-associated infections caused by S. aureus.Entities:
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Year: 2007 PMID： 18328762 DOI： 10.1016/j.micinf.2007.11.006
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700