Literature DB >> 18328423

The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.

Qi Zeng1, Wanjin Hong.   

Abstract

The Hippo pathway defined originally in Drosophila melanogaster is conserved in mammals. The fly core components Hippo, Sav, Wts, and Mats are conserved in mammals as Mst1/2, WW45, LATS1/2, and Mob1. The pathway impinges on transcriptional coactivator Yorkie in fly and YAP in mammals to coordinate cell proliferation and apoptosis. Several recent publications establish that the pathway is one major conserved mechanism governing cell contact inhibition, organ size control, and cancer development. This advance opens new vistas in exploring fundamental mechanisms in cell and developmental biology and offers potential targets to interfere with cancer development.

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Year:  2008        PMID： 18328423     DOI： 10.1016/j.ccr.2008.02.011

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  213 in total

Review 1.  Involvement of members of the cadherin superfamily in cancer.

Authors:  Geert Berx; Frans van Roy
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-09-23       Impact factor: 10.005

2.  The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner.

Authors:  M Shanzer; I Ricardo-Lax; R Keshet; N Reuven; Y Shaul
Journal:  Oncogene       Date:  2014-11-03       Impact factor: 9.867

3.  MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.

Authors:  Bekir Cinar; Filiz Kisaayak Collak; Delia Lopez; Seckin Akgul; Nishit K Mukhopadhyay; Murat Kilicarslan; Daniel G Gioeli; Michael R Freeman
Journal:  Cancer Res       Date:  2011-04-21       Impact factor: 12.701

4.  Collective and single cell behavior in epithelial contact inhibition.

Authors:  Alberto Puliafito; Lars Hufnagel; Pierre Neveu; Sebastian Streichan; Alex Sigal; D Kuchnir Fygenson; Boris I Shraiman
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-06       Impact factor: 11.205

5.  Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.

Authors:  Kun Zhang; Eva Rodriguez-Aznar; Norikazu Yabuta; Robert J Owen; Jose M Mingot; Hiroshi Nojima; M Angela Nieto; Gregory D Longmore
Journal:  EMBO J       Date:  2011-09-27       Impact factor: 11.598

6.  Parole terms for a killer: directing caspase3/CAD induced DNA strand breaks to coordinate changes in gene expression.

Authors:  Brian D Larsen; Lynn A Megeney
Journal:  Cell Cycle       Date:  2010-08-01       Impact factor: 4.534

Review 7.  When pathways collide: collaboration and connivance among signalling proteins in development.

Authors:  Helen McNeill; James R Woodgett
Journal:  Nat Rev Mol Cell Biol       Date:  2010-05-12       Impact factor: 94.444

8.  Structural and functional analysis of the YAP-binding domain of human TEAD2.

Authors:  Wei Tian; Jianzhong Yu; Diana R Tomchick; Duojia Pan; Xuelian Luo
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-05       Impact factor: 11.205

9.  The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7.

Authors:  Steven G Chaulk; Victoria J Lattanzi; Samantha E Hiemer; Richard P Fahlman; Xaralabos Varelas
Journal:  J Biol Chem       Date:  2013-12-09       Impact factor: 5.157

10.  The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.

Authors:  Sonali Jalan Rawat; Caretha L Creasy; Jeffrey R Peterson; Jonathan Chernoff
Journal:  J Biol Chem       Date:  2013-02-05       Impact factor: 5.157
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