Literature DB >> 18327266

Genetic control of neuronal activity in mice conditionally expressing TRPV1.

Benjamin R Arenkiel1, Marguerita E Klein, Ian G Davison, Lawrence C Katz, Michael D Ehlers.   

Abstract

Here we describe a knock-in mouse model for Cre-loxP-based conditional expression of TRPV1 in central nervous system neurons. Expression of Cre recombinase using biolistics, lentivirus or genetic intercrosses triggered heterologous expression of TRPV1 in a cell-specific manner. Application of the TRPV1 ligand capsaicin induced strong inward currents, triggered action potentials and activated stereotyped behaviors, allowing cell type-specific chemical genetic control of neuronal activity in vitro and in vivo.

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Year:  2008        PMID： 18327266      PMCID： PMC3127246          DOI： 10.1038/nmeth.1190

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  14 in total

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Authors:  M J Caterina; M A Schumacher; M Tominaga; T A Rosen; J D Levine; D Julius
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Authors:  Wolfgang Liedtke; David M Tobin; Cornelia I Bargmann; Jeffrey M Friedman
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Journal:  PLoS One       Date:  2007-03-21       Impact factor: 3.240
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