Literature DB >> 183266

Cytokine inhibition of DNA synthesis: effect on cyclic adenosine monophosphate in lymphocytes.

B V Jegasothy, A R Pachner, B H Waksman.   

Abstract

A greater than twofold increase in intracellular adenosine 3',5'-monophosphate (cyclic AMP) inhibited DNA synthesis, in stimulated rat lymphocytes. A two- to fourfold rise of intracellular cyclic AMP, starting at 16 hours, was produced by purified inhibitor od DNA synthesis added to such cells either at 0 or 16 hours, in close association with the initiation of DNA synthesis.

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Year:  1976        PMID： 183266     DOI： 10.1126/science.183266

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  Effects of osteoclast activating factor from human lymphocytes on cyclic AMP concentrations in isolated mouse bone and bone cells.

Authors:  R A Luben; M C Chen; D M Rosen; M A Mohler
Journal:  Calcif Tissue Int       Date:  1979-08-24       Impact factor: 4.333

Review 2.  Tolerance, the thymus, and suppressor T cells.

Authors:  B H Waksman
Journal:  Clin Exp Immunol       Date:  1977-06       Impact factor: 4.330

3.  Regulatory substances produced by lymphocytes. VI. Cell cycle specificity of inhibitor of DNA synthesis action in L cells.

Authors:  A B Wagshal; B V Jegasothy; B H Waksman
Journal:  J Exp Med       Date:  1978-01-01       Impact factor: 14.307

4.  Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

Authors:  J H Korn; P V Halushka; E C LeRoy
Journal:  J Clin Invest       Date:  1980-02       Impact factor: 14.808

5.  Immuno-suppressive lymphocyte factors. I. Purification of inhibitor of DNA synthesis to homogeneity.

Authors:  B V Jegasothy; D R Battles
Journal:  J Exp Med       Date:  1979-09-19       Impact factor: 14.307
  5 in total

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