Literature DB >> 1832625

Characteristics of the new progestogens in combination oral contraceptives.

R W Rebar1, K Zeserson.   

Abstract

This review details the characteristic features of three new progestogens which soon will be available in low-dose combination oral contraceptive agents in the United States. Available data suggest that desogestrel, gestodene, and norgestimate are extremely potent progestogens with few androgenic side effects. The smaller changes in lipids induced by these progestogens seem to confer some advantage to the use of preparations containing one of these agents. Whether this advantage is also present clinically remains to be determined.

Entities:  

Keywords:  Biology; Blood Coagulation Effects; Carbohydrate Metabolic Effects; Contraception; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Contraceptive Methods--pharmacodynamics; Contraceptive Mode Of Action; Desogestrel--pharmacodynamics; Family Planning; Gestodene--pharmacodynamics; Hematological Effects; Hemic System; Lipid Metabolic Effects; Lipids; Metabolic Effects; Norgestimate--pharmacodynamics; Oral Contraceptives, Combined--pharmacodynamics; Oral Contraceptives--pharmacodynamics; Ovulation Suppression; Physiology

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Year:  1991        PMID: 1832625     DOI: 10.1016/0010-7824(91)90101-k

Source DB:  PubMed          Journal:  Contraception        ISSN: 0010-7824            Impact factor:   3.375


  4 in total

1.  New oral contraceptive progestogens.

Authors:  W B Harer
Journal:  West J Med       Date:  1992-06

Review 2.  Gestodene. A review of its pharmacology, efficacy and tolerability in combined contraceptive preparations.

Authors:  M I Wilde; J A Balfour
Journal:  Drugs       Date:  1995-08       Impact factor: 9.546

3.  Transactivation of progestin- and estrogen-responsive promoters by 19-nor progestins in African Green Monkey Kidney CV1 cells.

Authors:  A M Pasapera; R Gutiérrez-Sagal; R García-Becerra; A Ulloa-Aguirre; J F Savouret
Journal:  Endocrine       Date:  2001-12       Impact factor: 3.633

4.  Medroxyprogesterone acetate antagonizes the effects of estrogen treatment on social and sexual behavior in female macaques.

Authors:  Karen Pazol; Mark E Wilson; Kim Wallen
Journal:  J Clin Endocrinol Metab       Date:  2004-06       Impact factor: 5.958

  4 in total

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