Literature DB >> 1832599

Human colonic intra-epithelial lymphocytes are suppressor cells.

P Hoang1, H R Dalton, D P Jewell.   

Abstract

Human colonic intra-epithelial lymphocytes (IEL) suppress the proliferation of autologous lamina propria lymphocytes, but not autologous peripheral blood mononuclear cells, when stimulated with phytohaemagglutinin. This suppressor function is mediated by a CD8-dependent soluble factor and is not related to the expression of the gamma delta T cell receptor. These findings may be relevant to the induction of mucosal tolerance. However, there is no defect in suppressor activity of colonic IEL in inflammatory bowel disease.

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Year:  1991        PMID： 1832599      PMCID： PMC1535625          DOI： 10.1111/j.1365-2249.1991.tb05756.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  21 in total

Review 1.  Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes.

Authors:  P Brandtzaeg; T S Halstensen; K Kett; P Krajci; D Kvale; T O Rognum; H Scott; L M Sollid
Journal:  Gastroenterology       Date:  1989-12       Impact factor: 22.682

2.  Flow cytometric analysis of peripheral blood lymphocytes in ulcerative colitis and Crohn's disease.

Authors:  M Senju; F Hulstaert; J Lowder; D P Jewell
Journal:  Gut       Date:  1991-07       Impact factor: 23.059

3.  Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease.

Authors:  I Hirata; G Berrebi; L L Austin; D F Keren; W O Dobbins
Journal:  Dig Dis Sci       Date:  1986-06       Impact factor: 3.199

4.  Characterization of suppressor T cells for antibody production by chicken spleen cells. I. Antigen-induced suppressor cells are CT8+, TcR1+ (gamma delta) T cells.

Authors:  P Quere; M D Cooper; G J Thorbecke
Journal:  Immunology       Date:  1990-12       Impact factor: 7.397

5.  Expression of T-cell receptors TcR1 (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa.

Authors:  L K Trejdosiewicz; C J Smart; D J Oakes; P D Howdle; G Malizia; D Campana; A W Boylston
Journal:  Immunology       Date:  1989-09       Impact factor: 7.397

6.  Interactions of lymphoid cells with the epithelial environment.

Authors:  P Brandtzaeg; L M Sollid; K Bjerke; K Kett; D Kvale; T O Rognum; H Scott; P S Thrane
Journal:  Monogr Allergy       Date:  1988

7.  A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes.

Authors:  N Cerf-Bensussan; A Jarry; N Brousse; B Lisowska-Grospierre; D Guy-Grand; C Griscelli
Journal:  Eur J Immunol       Date:  1987-09       Impact factor: 5.532

8.  T cell and mononuclear phagocyte populations of the human small and large intestine.

Authors:  L K Trejdosiewicz; G Malizia; S Badr-el-Din; C J Smart; D J Oakes; J Southgate; P D Howdle; G Janossy; L W Poulter; M S Losowsky
Journal:  Adv Exp Med Biol       Date:  1987       Impact factor: 2.622

9.  Examination of the low proliferative capacity of human jejunal intraepithelial lymphocytes.

Authors:  E C Ebert; A I Roberts; R E Brolin; K Raska
Journal:  Clin Exp Immunol       Date:  1986-07       Impact factor: 4.330

10.  Evidence for function of Ia molecules on gut epithelial cells in man.

Authors:  L Mayer; R Shlien
Journal:  J Exp Med       Date:  1987-11-01       Impact factor: 14.307
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  8 in total

1.  What is the role of human intestinal intraepithelial lymphocytes?

Authors:  L K Trejdosiewicz
Journal:  Clin Exp Immunol       Date:  1993-12       Impact factor: 4.330

2.  Cytokine gene transcription of human colonic intraepithelial lymphocytes costimulated with epithelial cells bearing HLA-DR and its inhibition by 5-aminosalicylic acid.

Authors:  D Chen; G Radford-Smith; M C Dipaolo; I McGowan; D P Jewell
Journal:  J Clin Immunol       Date:  1996-07       Impact factor: 8.317

3.  Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens.

Authors:  H R Dalton; M C Dipaolo; G K Sachdev; B Crotty; P Hoang; D P Jewell
Journal:  Clin Exp Immunol       Date:  1993-07       Impact factor: 4.330

4.  Activation of human intraepithelial lymphocytes reduces CD3 expression.

Authors:  E C Ebert
Journal:  Clin Exp Immunol       Date:  2003-06       Impact factor: 4.330

5.  Human colonic intraepithelial lymphocytes suppress in vitro immunoglobulin synthesis by autologous peripheral blood lymphocytes and lamina propria lymphocytes.

Authors:  G K Sachdev; H R Dalton; P Hoang; M C DiPaolo; B Crotty; D P Jewell
Journal:  Gut       Date:  1993-02       Impact factor: 23.059

6.  Changes of CD8+CD28- T regulatory cells in rat model of colitis induced by 2,4-dinitrofluorobenzene.

Authors:  Wen-Bin Xiao; Yu-Lan Liu
Journal:  World J Gastroenterol       Date:  2003-11       Impact factor: 5.742

7.  Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset.

Authors:  P A Haslett; L G Corral; M Albert; G Kaplan
Journal:  J Exp Med       Date:  1998-06-01       Impact factor: 14.307

8.  Human colonic intraepithelial lymphocytes regulate the cytokines produced by lamina propria mononuclear cells.

Authors:  P Hoang; J P Dehennin; L Li; C Sibille; A Geubel; J P Vaerman
Journal:  Mediators Inflamm       Date:  1997       Impact factor: 4.711
  8 in total

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