| Literature DB >> 18325768 |
Antonio Garrido Montalban1, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G J Delaet, Eric Erb, Justin T Ernst, Andrew Gibbs, Jeffrey Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi, Edward Roberts, Eddine Saiah, Robert Sullivan, Zhijun Wang, Christopher J Larson.
Abstract
We have identified a novel series of potent p38 MAP kinase inhibitors through structure-based design which due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In vitro ADME and in vivo PK studies show these compounds to have drug-like characteristics which could result in the development of an oral treatment for inflammatory conditions.Entities:
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Year: 2008 PMID： 18325768 DOI： 10.1016/j.bmcl.2008.02.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823