Literature DB >> 18325344

Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the destabilization of TSC-22.

Jeong Heon Lee1, Seung Bae Rho, Sang-Yoon Park, Taehoon Chun.   

Abstract

Yeast two-hybrid screening was conducted using a human ovary cDNA library to search for a novel binding protein using transforming growth factor-beta stimulated clone-22 (TSC-22). The selected protein was fortilin, which has been characterized as a nuclear anti-apoptotic protein. Overexpression of fortilin in ovarian carcinoma cells reversed TSC-22-mediated apoptosis, and the inhibition of fortilin expression via small interfering RNA (siRNA) resulted in an increase in the apoptosis of ovarian carcinoma cells. Moreover, fortilin overexpression promoted the degradation of TSC-22. Thus, an interaction between fortilin and TSC-22 prevents apoptosis via the destabilization of TSC-22 in ovarian carcinoma cells.

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Year:  2008        PMID： 18325344     DOI： 10.1016/j.febslet.2008.01.066

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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Journal:  J Biol Chem       Date:  2011-07-27       Impact factor: 5.157

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Journal:  Biochim Biophys Acta       Date:  2009-02-07

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Authors:  Abhijnan Chattopadhyay; Decha Pinkaew; Hung Q Doan; Reed B Jacob; Sunil K Verma; Hana Friedman; Alan C Peterson; Muge N Kuyumcu-Martinez; Owen M McDougal; Ken Fujise
Journal:  Sci Rep       Date:  2016-01-04       Impact factor: 4.379

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Journal:  Nat Commun       Date:  2017-05-26       Impact factor: 14.919
  8 in total

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