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Literature DB >> 18322668

The (pro)renin receptors.

Abstract

Two (pro)renin receptors have been characterized so far, the mannose-6-phosphate receptor (M6P-R) and a specific receptor called (P)RR for (pro)renin receptor. Each receptor controls a different aspect of renin and prorenin metabolism. The M6P-R is a clearance receptor, whereas (P)RR mediates their cellular effects by activating intracellular signaling and up-regulating gene expression. Moreover, binding to (P)RR increases renin enzymatic activity and fully activates prorenin, the inactive proenzyme form of renin. Experimental models suggest that increased (P)RR synthesis and/or activation may be relevant to diseases, especially to high blood pressure, to cardiac fibrosis associated with hypertension, and to diabetic nephropathy.

Entities: Disease Gene

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Year: 2008 PMID： 18322668 DOI： 10.1007/s00109-008-0319-1

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

22 in total

1. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II.

Authors: Jasper J Saris; Peter A C 't Hoen; Ingrid M Garrelds; Dick H W Dekkers; Johan T den Dunnen; Jos M J Lamers; A H Jan Danser
Journal: Hypertension Date: 2006-08-28 Impact factor: 10.190

2. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein.

Authors: Jan H Schefe; Mario Menk; Jana Reinemund; Karin Effertz; Robin M Hobbs; Pier Paolo Pandolfi; Patricia Ruiz; Thomas Unger; Heiko Funke-Kaiser
Journal: Circ Res Date: 2006-11-02 Impact factor: 17.367

3. A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor.

Authors: Juliane Ramser; Fatima E Abidi; Celine A Burckle; Claus Lenski; Helga Toriello; Gaiping Wen; Herbert A Lubs; Stefanie Engert; Roger E Stevenson; Alfons Meindl; Charles E Schwartz; Genevieve Nguyen
Journal: Hum Mol Genet Date: 2005-03-03 Impact factor: 6.150

4. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin.

Authors: Atsuhiro Ichihara; Matsuhiko Hayashi; Yuki Kaneshiro; Fumiaki Suzuki; Tsutomu Nakagawa; Yuko Tada; Yukako Koura; Akira Nishiyama; Hirokazu Okada; M Nasir Uddin; A H M Nurun Nabi; Yuichi Ishida; Tadashi Inagami; Takao Saruta
Journal: J Clin Invest Date: 2004-10 Impact factor: 14.808

5. Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats.

Authors: Yuki Kaneshiro; Atsuhiro Ichihara; Mariyo Sakoda; Tomoko Takemitsu; A H M Nurun Nabi; M Nasir Uddin; Tsutomu Nakagawa; Akira Nishiyama; Fumiaki Suzuki; Tadashi Inagami; Hiroshi Itoh
Journal: J Am Soc Nephrol Date: 2007-05-09 Impact factor: 10.121

6. Targeting TGF-beta overexpression in renal disease: maximizing the antifibrotic action of angiotensin II blockade.

Authors: H Peters; W A Border; N A Noble
Journal: Kidney Int Date: 1998-11 Impact factor: 10.612

7. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide.

Authors: Sandra Feldt; Wendy W Batenburg; Istvan Mazak; Ulrike Maschke; Maren Wellner; Heda Kvakan; Ralf Dechend; Anette Fiebeler; Celine Burckle; Aurelie Contrepas; A H Jan Danser; Michael Bader; Genevieve Nguyen; Friedrich C Luft; Dominik N Muller
Journal: Hypertension Date: 2008-01-22 Impact factor: 10.190

8. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats.

Authors: C Krebs; I Hamming; S Sadaghiani; O M Steinmetz; C Meyer-Schwesinger; S Fehr; R A K Stahl; I M Garrelds; A H J Danser; H van Goor; A Contrepas; G Nguyen; U Wenzel
Journal: Kidney Int Date: 2007-06-27 Impact factor: 10.612

9. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.

Authors: Y Huang; S Wongamorntham; J Kasting; D McQuillan; R T Owens; L Yu; N A Noble; W Border
Journal: Kidney Int Date: 2006-01 Impact factor: 18.998

10. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells.

Authors: Y Huang; N A Noble; J Zhang; C Xu; W A Border
Journal: Kidney Int Date: 2007-03-28 Impact factor: 18.998

8 in total

1. Aging, Angiotensin system and dopaminergic degeneration in the substantia nigra.

Authors: Jose L Labandeira-Garcia; Jannette Rodriguez-Pallares; Begoña Villar-Cheda; Ana I Rodríguez-Perez; Pablo Garrido-Gil; Maria J Guerra
Journal: Aging Dis Date: 2011-04-20 Impact factor: 6.745

Review 2. Is the renin-angiotensin system actually hypertensive?

Authors: Etienne Bérard; Olivier Niel; Amandine Rubio
Journal: Pediatr Nephrol Date: 2013-06-06 Impact factor: 3.714

3. Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease.

Authors: Jose L Labandeira-Garcia; Jannette Rodriguez-Pallares; Ana I Rodríguez-Perez; Pablo Garrido-Gil; Begoña Villar-Cheda; Rita Valenzuela; Maria J Guerra
Journal: Am J Neurodegener Dis Date: 2012-11-18

Review 4. A current view of brain renin-angiotensin system: Is the (pro)renin receptor the missing link?

Authors: Adolfo E Cuadra; Zhiying Shan; Colin Sumners; Mohan K Raizada
Journal: Pharmacol Ther Date: 2009-08-31 Impact factor: 12.310

Review 5. The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man.

Authors: Alessandra Del Fiorentino; Silvana Cianchetti; Alessandro Celi; Giulia Dell'Omo; Roberto Pedrinelli
Journal: Vasc Health Risk Manag Date: 2009-04-08