BACKGROUND: Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). Studies are being carried out to determine how best to utilize this characteristic in treatments for conditions such as chronic hand dermatitis. OBJECTIVE: To review the literature on alitretinoin. METHODS: The scope of the review encompasses ways that alitretinoin is currently and may potentially be utilized. RESULTS/ CONCLUSIONS: Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. Topical treatment with alitretinoin can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Despite these benefits, oral alitretinoin will face a difficult path attaining approval for use in the US.
BACKGROUND:Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). Studies are being carried out to determine how best to utilize this characteristic in treatments for conditions such as chronic hand dermatitis. OBJECTIVE: To review the literature on alitretinoin. METHODS: The scope of the review encompasses ways that alitretinoin is currently and may potentially be utilized. RESULTS/ CONCLUSIONS: Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. Topical treatment with alitretinoin can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Despite these benefits, oral alitretinoin will face a difficult path attaining approval for use in the US.
Authors: D C Soler; X Bai; L Ortega; T Pethukova; S T Nedorost; D L Popkin; K D Cooper; T S McCormick Journal: Med Hypotheses Date: 2015-02-11 Impact factor: 1.538
Authors: Maureen A Kane; Alexandra E Folias; Attilio Pingitore; Mariarita Perri; Kristin M Obrochta; Charles R Krois; Erika Cione; Joo Yeon Ryu; Joseph L Napoli Journal: Proc Natl Acad Sci U S A Date: 2010-11-29 Impact factor: 11.205