PURPOSE: Many existing and new drugs fail to be fully utilized because of their limited bioavailability due to poor solubility in aqueous media. Given the emerging importance of using nanoparticles as a promising way to enhance the dissolution rate of these drugs, a method must be developed to adequately reflect the rate-change due to size reduction. At present, there is little published work examining the suitability of different dissolution apparatus for nanoparticles. METHODS: Four commonly-used methods (the paddle, rotating basket and flow-through cell from the US Pharmacopia, and a dialysis method) were employed to measure the dissolution rates of cefuroxime axetil as a model for nanodrug particles. RESULTS: Experimental rate ratios between the nanoparticles and their unprocessed form were 6.95, 1.57 and 1.00 for the flow-through, basket and paddle apparatus respectively. In comparison, the model-predicted value was 7.97. Dissolution via dialysis was rate-limited by the membrane. CONCLUSIONS: The data showed the flow-through cell to be unequivocally the most robust dissolution method for the nanoparticulate system. Furthermore, the dissolution profiles conform closely to the classic Noyes-Whitney model, indicating that the increase in dissolution rate as particles become smaller results from the increase in surface area and solubility of the nanoparticles.
PURPOSE: Many existing and new drugs fail to be fully utilized because of their limited bioavailability due to poor solubility in aqueous media. Given the emerging importance of using nanoparticles as a promising way to enhance the dissolution rate of these drugs, a method must be developed to adequately reflect the rate-change due to size reduction. At present, there is little published work examining the suitability of different dissolution apparatus for nanoparticles. METHODS: Four commonly-used methods (the paddle, rotating basket and flow-through cell from the US Pharmacopia, and a dialysis method) were employed to measure the dissolution rates of cefuroxime axetil as a model for nanodrug particles. RESULTS: Experimental rate ratios between the nanoparticles and their unprocessed form were 6.95, 1.57 and 1.00 for the flow-through, basket and paddle apparatus respectively. In comparison, the model-predicted value was 7.97. Dissolution via dialysis was rate-limited by the membrane. CONCLUSIONS: The data showed the flow-through cell to be unequivocally the most robust dissolution method for the nanoparticulate system. Furthermore, the dissolution profiles conform closely to the classic Noyes-Whitney model, indicating that the increase in dissolution rate as particles become smaller results from the increase in surface area and solubility of the nanoparticles.
Authors: Peng Liu; Odile De Wulf; Johanna Laru; Teemu Heikkilä; Bert van Veen; Juha Kiesvaara; Jouni Hirvonen; Leena Peltonen; Timo Laaksonen Journal: AAPS PharmSciTech Date: 2013-04-25 Impact factor: 3.246
Authors: Suzanne M D'Addio; Abdallah A Bukari; Mohammed Dawoud; Heike Bunjes; Carlos Rinaldi; Robert K Prud'homme Journal: Philos Trans A Math Phys Eng Sci Date: 2016-07-28 Impact factor: 4.226
Authors: Wenbo Wang; Qi Tony Zhou; Si-Ping Sun; John A Denman; Thomas R Gengenbach; Nicolas Barraud; Scott A Rice; Jian Li; Mingshi Yang; Hak-Kim Chan Journal: AAPS J Date: 2015-11-24 Impact factor: 4.009