Literature DB >> 18320273

Aminoglycoside-resistance mechanisms in multidrug-resistant Staphylococcus aureus clinical isolates.

R Kelmani Chandrakanth1, S Raju, S A Patil.   

Abstract

Aminoglycoside resistance in six clinically isolated Staphylococcus aureus was evaluated. Genotypical examination revealed that three isolates (HLGR-10, HLGR-12, and MSSA-21) have aminoglycoside-modifying enzyme (AME) coding genes and another three (GRSA-2, GRSA-4, and GRSA-6) lacked these genes in their genome. Whereas isolates HLGR-10 and HLGR-14 possessed bifunctional AME coding gene aac(6')-aph(2''), and aph(3')-III and showed high-level resistance to gentamycin and streptomycin, MSSA-21 possessed aph(3')-III and exhibited low resistance to gentamycin, streptomycin, and kanamycin. The remaining three isolates (GRSA-2, GRSA-4, and GRSA-6) exhibited low resistance to all the aminoglycosides because they lack aminoglycoside-modifying enzyme coding genes in their genome. The transmission electron microscopy of the three isolates revealed changes in cell size, shape, and septa formation, supporting the view that the phenomenon of adaptive resistance is operative in these isolates.

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Year:  2008        PMID： 18320273     DOI： 10.1007/s00284-008-9123-y

Source DB:  PubMed          Journal:  Curr Microbiol        ISSN： 0343-8651            Impact factor:   2.188


  24 in total

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Journal:  J Clin Microbiol       Date:  2001-09       Impact factor: 5.948

2.  In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations.

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Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

4.  Nomenclature of genes encoding aminoglycoside-modifying enzymes.

Authors:  R Vanhoof; E Hannecart-Pokorni; J Content
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

5.  In-vitro activity of arbekacin alone and in combination with vancomycin against gentamicin- and methicillin-resistant Staphylococcus aureus.

Authors:  I You; R Kariyama; M J Zervos; H Kumon; J W Chow
Journal:  Diagn Microbiol Infect Dis       Date:  2000-01       Impact factor: 2.803

Review 6.  Aminoglycoside uptake and mode of action--with special reference to streptomycin and gentamicin. I. Antagonists and mutants.

Authors:  R E Hancock
Journal:  J Antimicrob Chemother       Date:  1981-10       Impact factor: 5.790

7.  Synergistic killing of vancomycin-resistant enterococci of classes A, B, and C by combinations of vancomycin, penicillin, and gentamicin.

Authors:  D M Shlaes; L Etter; L Gutmann
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Review 8.  The aminoglycosides.

Authors:  R S Edson; C L Terrell
Journal:  Mayo Clin Proc       Date:  1999-05       Impact factor: 7.616

Review 9.  Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

Authors:  K J Shaw; P N Rather; R S Hare; G H Miller
Journal:  Microbiol Rev       Date:  1993-03

10.  Gentamicin uptake in Staphylococcus aureus possessing plasmid-encoded, aminoglycoside-modifying enzymes.

Authors:  L J Mandel; E Murphy; N H Steigbigel; M H Miller
Journal:  Antimicrob Agents Chemother       Date:  1984-10       Impact factor: 5.191
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Journal:  BMC Res Notes       Date:  2014-11-25

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Journal:  Antibiotics (Basel)       Date:  2021-04-10

Review 4.  Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.

Authors:  Beata Mlynarczyk-Bonikowska; Cezary Kowalewski; Aneta Krolak-Ulinska; Wojciech Marusza
Journal:  Int J Mol Sci       Date:  2022-07-22       Impact factor: 6.208

5.  Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs.

Authors:  Erica C Pehrsson; Kevin J Forsberg; Molly K Gibson; Sara Ahmadi; Gautam Dantas
Journal:  Front Microbiol       Date:  2013-06-07       Impact factor: 5.640

6.  Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.

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  6 in total

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