OBJECTIVE: Cystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function. RESEARCH DESIGN AND METHODS: Glomerular filtration rate (GFR) was monitored over a mean of 10.1 years in 85 subjects with type 1 diabetes (with an average of 5.6 measurements per individual). Baseline mean +/- SD iGFR of the cohort was 106.1 +/- 2.6 ml/min per 1.73 m(2). The rates of decline in GFR (DeltaGFR) were derived using linear regression. RESULTS: In 19 of 85 subjects with declining renal function (i.e., DeltaiGFR >3.3 ml/min per 1.73 m(2) per year), DeltaGFR (ml/min per 1.73 m(2) per year) was 6.5 by iGFR, 4.2 by 10(4)/creatinine, 3.6 by Cockcroft-Gault formula, 3.4 by the Modification of Diet in Renal Disease (MDRD)-6 equation, and 3.5 by the MDRD-4 variable equation (P < 0.01 vs. iGFR). In comparison, DeltaGFR was 6.1 using the formula Cys-GFR = (86.7/cystatin C concentration) - 4.2 (not significant). CONCLUSIONS: Cystatin C was more accurate in detecting decline in renal function than creatinine-based methods in this population of subjects with type 1 diabetes and a normal mean baseline GFR.
OBJECTIVE:Cystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function. RESEARCH DESIGN AND METHODS: Glomerular filtration rate (GFR) was monitored over a mean of 10.1 years in 85 subjects with type 1 diabetes (with an average of 5.6 measurements per individual). Baseline mean +/- SD iGFR of the cohort was 106.1 +/- 2.6 ml/min per 1.73 m(2). The rates of decline in GFR (DeltaGFR) were derived using linear regression. RESULTS: In 19 of 85 subjects with declining renal function (i.e., DeltaiGFR >3.3 ml/min per 1.73 m(2) per year), DeltaGFR (ml/min per 1.73 m(2) per year) was 6.5 by iGFR, 4.2 by 10(4)/creatinine, 3.6 by Cockcroft-Gault formula, 3.4 by the Modification of Diet in Renal Disease (MDRD)-6 equation, and 3.5 by the MDRD-4 variable equation (P < 0.01 vs. iGFR). In comparison, DeltaGFR was 6.1 using the formula Cys-GFR = (86.7/cystatin C concentration) - 4.2 (not significant). CONCLUSIONS:Cystatin C was more accurate in detecting decline in renal function than creatinine-based methods in this population of subjects with type 1 diabetes and a normal mean baseline GFR.
Authors: David M Maahs; Janet K Snell-Bergeon; John E Hokanson; Gregory L Kinney; Tomas Berl; Marian Rewers; Lorraine G Ogden Journal: Diabetes Technol Ther Date: 2010-01 Impact factor: 6.118
Authors: Anders Frid; Gunnar N Sterner; Magnus Löndahl; Clara Wiklander; Anne Cato; Ellen Vinge; Anders Andersson Journal: Diabetes Care Date: 2010-03-09 Impact factor: 19.112
Authors: Louise J Maple-Brown; Paul D Lawton; Jaquelyne T Hughes; Suresh K Sharma; Graham Rd Jones; Andrew G Ellis; Wendy Hoy; Alan Cass; Richard J Macisaac; Ashim K Sinha; Mark Ab Thomas; Leonard S Piers; Leigh C Ward; Katrina Drabsch; Sianna Panagiotopoulos; Robyn McDermott; Kevin Warr; Sajiv Cherian; Alex Brown; George Jerums; Kerin O'Dea Journal: BMC Public Health Date: 2010-02-19 Impact factor: 3.295
Authors: Linda H Ficociello; Elizabeth T Rosolowsky; Monika A Niewczas; Nicholas J Maselli; Janice M Weinberg; Ann Aschengrau; John H Eckfeldt; Robert C Stanton; Andrzej T Galecki; Alessandro Doria; James H Warram; Andrzej S Krolewski Journal: Diabetes Care Date: 2010-03-23 Impact factor: 17.152
Authors: Linda H Ficociello; Bruce A Perkins; Bijan Roshan; Janice M Weinberg; Ann Aschengrau; James H Warram; Andrzej S Krolewski Journal: Diabetes Care Date: 2009-02-05 Impact factor: 19.112