| Literature DB >> 18318116 |
E V Spitsina, N Iu Iakunina, D A Chudakova, A G Nikitin, G N Svetlova, T N Soluianova, I A Strokov, V V Nosikov.
Abstract
The aim of this study was the search of association of polymorphous markers Pro72Arg and C(-594)CC of TP53 gene with diabetic polyneuropathy (DPN) in patients with type 1 diabetes mellitus with or without clinical signs of DPN. We have found that polymorphous marker Pro72Arg of TP53 gene was associated with DPN in Russian patients with type 1 diabetes mellitus living in Moscow. The carriers of Arg allele and Arg/Arg genotype had higher risk of DPN development (OR = 1.96; CI = 1.32-2.90; and OR = 2.14; CI = 1.23-3.73; relatively). On the contrary, the carriage of Pro allele was associated with the lower risk of DPN development (OR = 0.51; CI = 0.34-0.76). We have not found any association of polymorphous marker C(-594)CC of TP53 gene with DPN in Russian patients with type 1 diabetes mellitus living in Moscow.Entities:
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Year: 2007 PMID： 18318116
Source DB: PubMed Journal: Mol Biol (Mosk) ISSN： 0026-8984