Literature DB >> 18317728

Beta cell mass in diabetes: a realistic therapeutic target?

J J Meier1.   

Abstract

Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement of beta cell function is therefore the logical long-term solution to therapy. This review sets out to describe the defects in beta cell mass and function in both forms of diabetes, summarises current understanding of the underlying causes of beta cell death, and the methodological limitations of determining beta cell mass in vivo. Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered.

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Year:  2008        PMID： 18317728     DOI： 10.1007/s00125-008-0936-9

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  98 in total

1.  Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion.

Authors:  S Bonner-Weir; D Deery; J L Leahy; G C Weir
Journal:  Diabetes       Date:  1989-01       Impact factor: 9.461

2.  In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts.

Authors:  N Pørksen; B Nyholm; J D Veldhuis; P C Butler; O Schmitz
Journal:  Am J Physiol       Date:  1997-11

3.  A morphological study of the endocrine pancreas in human pregnancy.

Authors:  F A Van Assche; L Aerts; F De Prins
Journal:  Br J Obstet Gynaecol       Date:  1978-11

4.  Pathologic anatomy of the pancreas in juvenile diabetes mellitus.

Authors:  W Gepts
Journal:  Diabetes       Date:  1965-10       Impact factor: 9.461

5.  Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes.

Authors:  G Klöppel; C R Drenck; M Oberholzer; P U Heitz
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1984

6.  Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig.

Authors:  L L Kjems; B M Kirby; E M Welsh; J D Veldhuis; M Straume; S S McIntyre; D Yang; P Lefèbvre; P C Butler
Journal:  Diabetes       Date:  2001-09       Impact factor: 9.461

7.  Cyclosporine delays but does not prevent clinical onset in glucose intolerant pre-type 1 diabetic children.

Authors:  J C Carel; C Boitard; G Eisenbarth; J F Bach; P F Bougnères
Journal:  J Autoimmun       Date:  1996-12       Impact factor: 7.094

8.  Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.

Authors:  Loredana Farilla; Angela Bulotta; Boaz Hirshberg; Sergio Li Calzi; Nasif Khoury; Houtan Noushmehr; Cristina Bertolotto; Umberto Di Mario; David M Harlan; Riccardo Perfetti
Journal:  Endocrinology       Date:  2003-08-28       Impact factor: 4.736

9.  Quantitative study of insulin secretion and clearance in normal and obese subjects.

Authors:  K S Polonsky; B D Given; L Hirsch; E T Shapiro; H Tillil; C Beebe; J A Galloway; B H Frank; T Karrison; E Van Cauter
Journal:  J Clin Invest       Date:  1988-02       Impact factor: 14.808

10.  Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

Authors:  Alexandra E Butler; Juliette Janson; Walter C Soeller; Peter C Butler
Journal:  Diabetes       Date:  2003-09       Impact factor: 9.461
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  50 in total

1.  Human beta cell proliferation by glucose--a complex scenario.

Authors:  M Tiedge
Journal:  Diabetologia       Date:  2010-12-21       Impact factor: 10.122

Review 2.  Do statins cause diabetes?

Authors:  Mark R Goldstein; Luca Mascitelli
Journal:  Curr Diab Rep       Date:  2013-06       Impact factor: 4.810

3.  Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration.

Authors:  Shuyuan Chen; Masayuki Shimoda; Jiaxi Chen; Shinichi Matsumoto; Paul A Grayburn
Journal:  Cell Cycle       Date:  2012-02-15       Impact factor: 4.534

Review 4.  Risk factors preceding type 2 diabetes and cardiomyopathy.

Authors:  Shamjeet Singh; Sanjiv Dhingra; Dan D Ramdath; Sudesh Vasdev; Vicki Gill; Pawan K Singal
Journal:  J Cardiovasc Transl Res       Date:  2010-07-01       Impact factor: 4.132

5.  Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset.

Authors:  Susan J Burke; Michael D Karlstad; Adrianna E Eder; Kellie M Regal; Danhong Lu; David H Burk; J Jason Collier
Journal:  Biofactors       Date:  2016-06-21       Impact factor: 6.113

6.  Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1.

Authors:  Shuyuan Chen; Raul A Bastarrachea; Brad J Roberts; V Saroja Voruganti; Patrice A Frost; Edna J Nava-Gonzalez; Hector E Arriaga-Cazares; Jiaxi Chen; Pintong Huang; Ralph A DeFronzo; Anthony G Comuzzie; Paul A Grayburn
Journal:  Cell Cycle       Date:  2014-02-10       Impact factor: 4.534

Review 7.  Benefit-risk assessment of exenatide in the therapy of type 2 diabetes mellitus.

Authors:  Baptist Gallwitz
Journal:  Drug Saf       Date:  2010-02-01       Impact factor: 5.606

8.  Beta-cell replication is increased in donor organs from young patients after prolonged life support.

Authors:  Peter In't Veld; Neelke De Munck; Kristien Van Belle; Nicole Buelens; Zhidong Ling; Ilse Weets; Patrick Haentjens; Miriam Pipeleers-Marichal; Frans Gorus; Daniel Pipeleers
Journal:  Diabetes       Date:  2010-04-22       Impact factor: 9.461

9.  Are we overestimating the loss of beta cells in type 2 diabetes?

Authors:  Lorena Marselli; Mara Suleiman; Matilde Masini; Daniela Campani; Marco Bugliani; Farooq Syed; Luisa Martino; Daniele Focosi; Fabrizio Scatena; Francesco Olimpico; Franco Filipponi; Pellegrino Masiello; Ugo Boggi; Piero Marchetti
Journal:  Diabetologia       Date:  2014-02       Impact factor: 10.122

10.  Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome.

Authors:  Kevin D Hill; Aaron W Eckhauser; Annis Marney; Nancy J Brown
Journal:  Diabetes Care       Date:  2009-02-05       Impact factor: 19.112
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