AIMS/HYPOTHESIS: The aim of our study was to assess the associations of serum alpha- and gamma-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus. METHODS: A case-control study with 108 cases with advanced beta cell autoimmunity and 216 matched control participants nested within the birth cohort of the Type 1 Diabetes Prediction and Prevention Project. A serum sample for vitamin E analyses was collected from all the children in the cohort at the age of 1 year and thereafter at 12 month intervals. For each case-control group, all the repeated serum samples up to the age of seroconversion to autoantibody positivity in the case were analysed. A conditional logistic regression model was used to determine potential associations between seroconversion and serum tocopherol concentrations. RESULTS: Serum alpha- or gamma-tocopherol concentrations were not significantly associated with the risk of advanced beta cell autoimmunity. The odds ratio (95% CI) for micromol/l increase in serum concentration of the first-year sample was 0.97 (0.92-1.03) for alpha-tocopherol and 1.10 (0.70-1.74) for gamma-tocopherol. However, there was an interaction between high values of gamma-tocopherol at the age of 1 year and the time of seroconversion (p = 0.024). CONCLUSIONS/ INTERPRETATION: It seems unlikely that high concentrations of alpha- or gamma-tocopherol protect against advanced beta cell autoimmunity in young children.
AIMS/HYPOTHESIS: The aim of our study was to assess the associations of serum alpha- and gamma-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus. METHODS: A case-control study with 108 cases with advanced beta cell autoimmunity and 216 matched control participants nested within the birth cohort of the Type 1 Diabetes Prediction and Prevention Project. A serum sample for vitamin E analyses was collected from all the children in the cohort at the age of 1 year and thereafter at 12 month intervals. For each case-control group, all the repeated serum samples up to the age of seroconversion to autoantibody positivity in the case were analysed. A conditional logistic regression model was used to determine potential associations between seroconversion and serum tocopherol concentrations. RESULTS: Serum alpha- or gamma-tocopherol concentrations were not significantly associated with the risk of advanced beta cell autoimmunity. The odds ratio (95% CI) for micromol/l increase in serum concentration of the first-year sample was 0.97 (0.92-1.03) for alpha-tocopherol and 1.10 (0.70-1.74) for gamma-tocopherol. However, there was an interaction between high values of gamma-tocopherol at the age of 1 year and the time of seroconversion (p = 0.024). CONCLUSIONS/ INTERPRETATION: It seems unlikely that high concentrations of alpha- or gamma-tocopherol protect against advanced beta cell autoimmunity in young children.
Authors: S Sasaki; F Ushio; K Amano; M Morihara; O Todoriki; Y Uehara; E Toyooka Journal: J Nutr Sci Vitaminol (Tokyo) Date: 2000-12 Impact factor: 2.000
Authors: Liisa Uusitalo; Mikael Knip; Michael G Kenward; Georg Alfthan; Jouko Sundvall; Antti Aro; Antti Reunanen; Hans K Akerblom; Suvi M Virtanen Journal: J Pediatr Endocrinol Metab Date: 2005-12 Impact factor: 1.634
Authors: S M Virtanen; M G Kenward; M Erkkola; S Kautiainen; C Kronberg-Kippilä; T Hakulinen; S Ahonen; L Uusitalo; S Niinistö; R Veijola; O Simell; J Ilonen; M Knip Journal: Diabetologia Date: 2006-04-05 Impact factor: 10.122
Authors: T Byers; F Trieber; E Gunter; R Coates; A Sowell; S Leonard; A Mokdad; S Jewell; D Miller; M Serdula Journal: Epidemiology Date: 1993-07 Impact factor: 4.822
Authors: Liisa Uusitalo; Jaakko Nevalainen; Irma Salminen; Marja-Leena Ovaskainen; Carina Kronberg-Kippilä; Suvi Ahonen; Sari Niinistö; Georg Alfthan; Olli Simell; Jorma Ilonen; Riitta Veijola; Mikael Knip; Suvi M Virtanen Journal: Matern Child Nutr Date: 2011-11-08 Impact factor: 3.092
Authors: L Marjamäki; S Niinistö; M G Kenward; L Uusitalo; U Uusitalo; M-L Ovaskainen; C Kronberg-Kippilä; O Simell; R Veijola; J Ilonen; M Knip; S M Virtanen Journal: Diabetologia Date: 2010-04-06 Impact factor: 10.122
Authors: Bryan Stanfill; Sarah Reehl; Lisa Bramer; Ernesto S Nakayasu; Stephen S Rich; Thomas O Metz; Marian Rewers; Bobbie-Jo Webb-Robertson Journal: Biomed Eng Comput Biol Date: 2019-07-15
Authors: Marianne Prasad; Hanna-Mari Takkinen; Liisa Uusitalo; Heli Tapanainen; Marja-Leena Ovaskainen; Georg Alfthan; Iris Erlund; Suvi Ahonen; Mari Åkerlund; Jorma Toppari; Jorma Ilonen; Mikael Knip; Riitta Veijola; Suvi M Virtanen Journal: Nutrients Date: 2018-10-17 Impact factor: 5.717